| Author | Viana, Graça Maria de Castro | |
| Author | Saldanha, Ana Cristina Rodrigues | |
| Author | Pinheiro, Clélia R | |
| Author | Nascimento, Jeanne d’Arc de Lisboa | |
| Author | Burattini, Marcelo Nascimento | |
| Author | Costa, Jackson Mauricio Lopes | |
| Access date | 2015-03-20T13:40:45Z | |
| Available date | 2015-03-20T13:40:45Z | |
| Document date | 2009 | |
| Citation | VIANA, G. M. C. et al. Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leishmaniais (AVL). Gazeta Médica da Bahia, v. 79, Supl 3, p. 156-162, 2009. | pt_BR |
| ISSN | 0016-545X | |
| URI | https://www.arca.fiocruz.br/handle/icict/9764 | |
| Language | eng | pt_BR |
| Publisher | Faculdade de Medicina da Universidade Federal da Bahia | pt_BR |
| Rights | open access | pt_BR |
| Title | Clinical trial with liposomal amphotericin B (AMBISOME®) for American Visceral Leisshmaniais (AVL) | pt_BR |
| Type | Article | pt_BR |
| Abstract | A prospective, non-randomized study was conducted on 30 patients with American Visceral Leishmaniasis (AVL)
aged 3 to 10 years from São Luis, Maranhão - Brazil, who were not previously submitted to treatment. After an
informed consent form, was signed by the responsible person, all patients were submitted to anamnesis and physical
examination and a standard chart was filled out. The patients were randomly divided into three cohorts of 10
patients each and submitted to the following treatment regimen with liposomal amphotericin B: cohort 1) 2 mg/kg/
day applied on days 1, 2, 3, 4, 5, 6 and 10, total dose of 14 mg/kg; cohort 2) 2 mg/kg/day applied on days 1, 2, 3, 4, and
10, total dose of 10 mg/kg; cohort 3) 2 mg/kg/day applied on days 1, 5, and 10, total dose of 6 mg/kg. An intra-hospital
treatment regimen was used which consisted of intravenous administration of the drug over a period of 60 min.
Efficacy was 70% in cohort 1, 90% cohort 2, and 80% in cohort 3. The patients were followed up for 6 months. No
significant difference was observed between the three regimens in terms of toxicity, tolerability and effectiveness
when evaluated by generalizations of the Gehan model and Wilcoxon test. | pt_BR |
| Affilliation | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil | pt_BR |
| Affilliation | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil | pt_BR |
| Affilliation | Federal University of São Paulo. Department of Infectious Diseases. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Leishmania chagasi | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Liposomal amphotericin B | pt_BR |
| Subject | Northeastern of Brazil | pt_BR |
