| Author | Brito, Gilberto N. O. | |
| Access date | 2015-03-20T13:56:48Z | |
| Available date | 2015-03-20T13:56:48Z | |
| Document date | 2009 | |
| Citation | BRITO, Gilberto N. O. Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective. Diabetol. metab. syndr., São Paulo, v. 1, n. 7, 2009. | pt_BR |
| ISSN | 1758-5996 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9782 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Title | Exercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspective | pt_BR |
| Type | Article | pt_BR |
| Abstract | The association of type II diabetes mellitus (DM2) with Alzheimer's disease (AD) has received
considerable attention in recent years. In the present paper, a hypothesis for this association from
an evolutionary perspective, with emphasis on the close interplay between exercise and cognitive
function, will be advanced in order to provide a biological rationale for the notion that the
fundamental metabolic features of DM2 act in the brain over a protracted time span to induce the
neuropathological characteristics of Alzheimer's disease thereby producing cognitive impairment.
It is hoped that this hypothesis puts the association of DM2 and AD on firm conceptual grounds
from a biological perspective and offers directions for further research. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Setor de Neurociências. Rio de Janeiro, RJ, Brasil. / Universidade Federal Fluminense. Instituto de Saúde daComunidade. Departamento de Psiquiatria e Saúde Mental. Niterói, RJ, Brasil. | pt_BR |
| DeCS | Diabetes Mellitus Tipo 2 | pt_BR |
| DeCS | Doença de Alzheimer | pt_BR |
