Mostrar el registro sencillo del ítem

AutorCabezas-Cruz, Alejandro
AutorLancelot, Julien
AutorCaby, Stéphanie
AutorOliveira, Guilherme Correa de
AutorPierce, Raymond John
Fecha de acceso2015-03-23T13:37:47Z
Fecha de disponibilización2015-03-23T13:37:47Z
Fecha de publicación2014
ReferenciaCABEZAS-CRUZ, Alejandro et al, Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet, v. 5, p. 317, 2014.pt_BR
ISSN1664-8021
URIhttps://www.arca.fiocruz.br/handle/icict/9805
Idiomaengpt_BR
EditorUniversity of Alabama at Birminghampt_BR
Derechos de autoropen accesspt_BR
TítuloEpigenetic control of gene function in schistosomes: a source of therapeutic targets?pt_BR
Tipo del documentoArticlept_BR
DOI10.3389/fgene.2014.00317
Resumen en InglésThe discovery of the epigenetic regulation of gene expression has revolutionized both our understanding of how genomes function and approaches to the therapy of numerous pathologies. Schistosomes are metazoan parasites and as such utilize most, if not all the epigenetic mechanisms in play in their vertebrate hosts: histone variants, histone tail modifications, non-coding RNA and, perhaps, DNA methylation. Moreover, we are acquiring an increasing understanding of the ways in which these mechanisms come into play during the complex schistosome developmental program. In turn, interest in the actors involved in epigenetic mechanisms, particularly the enzymes that carry out epigenetic modifications of histones or nucleic acid, as therapeutic targets has been stimulated by the finding that their inhibitors exert profound effects, not only on survival, but also on the reproductive function of Schistosoma mansoni. Here, we review our current knowledge, and what we can infer, about the role of epigenetic mechanisms in schistosome development, differentiation and survival. We will consider which epigenetic actors can be targeted for drug discovery and what strategies can be employed to develop potent, selective inhibitors as drugs to cure schistosomiasis.pt_BR
AfiliaciónUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, Francept_BR
AfiliaciónUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, Francept_BR
AfiliaciónUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, Francept_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelencia em Bioinformatica. Grupo de Biologia e Genômica Computational. Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazilpt_BR
AfiliaciónUniversité de Lille. Institut National de la Santé et de la Recherche Médicale. Centre National de la Recherche Scientifique. Institut Pasteur de Lille. Center for Infection and Immunity of Lille. Lille, Francept_BR
Palavras clave en Inglêsepigeneticspt_BR
Palavras clave en Inglêsschistosomept_BR
Palavras clave en Inglêsdrug discoverypt_BR
Palavras clave en Inglêshistone modifying enzymespt_BR
Palavras clave en InglêsDNA methylationpt_BR
Palavras clave en InglêsmicroRNAspt_BR


Ficheros en el ítem

application/pdf
Nombre:
2014_163.pdf
Tamaño:
2.382Mb
Formato:
application/
Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem