| Author | Oliveira, Ana Cristina Vanderley | |
| Author | Mota, Licia Maria Henrique da | |
| Author | Santos Neto, Leopoldo Luiz dos | |
| Author | Carvalho, Jozélio Freire De | |
| Author | Caldas, Iramaya Rodrigues | |
| Author | Martins Filho, Olindo Assis | |
| Author | Tauil, Pedro Luis | |
| Access date | 2015-03-23T19:14:13Z | |
| Available date | 2015-03-23T19:14:13Z | |
| Document date | 2014 | |
| Citation | OLIVEIRA, Ana Cristina Vanderley et al. Occurrence of Autoimmune Diseases Related to the Vaccine against Yellow Fever. Autoimmune Diseases, V. 2014, p. ID 473170, 2014. | pt_BR |
| ISSN | 2090-0422 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9813 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Title | Occurrence of Autoimmune Diseases Related to the Vaccine against Yellow Fever | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2014/473170 | |
| Abstract | Yellow fever is an infectious disease, endemic in South America and Africa. This is a potentially serious illness, with lethality between 5 and 40% of cases. The most effective preventive vaccine is constituted by the attenuated virus strain 17D, developed in 1937. It is considered safe and effective, conferring protection in more than 90% in 10 years. Adverse effects are known as mild reactions (allergies, transaminases transient elevation, fever, headache) and severe (visceral and neurotropic disease related to vaccine). However, little is known about its potential to induce autoimmune responses. This systematic review aims to identify the occurrence of autoinflammatory diseases related to 17D vaccine administration. Six studies were identified describing 13 possible cases. The diseases were Guillain-Barré syndrome, multiple sclerosis, multiple points evanescent syndrome, acute disseminated encephalomyelitis, autoimmune hepatitis, and Kawasaki disease. The data suggest that 17D vaccination may play a role in the mechanism of loss of self-tolerance. | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil/CRDF. Brasília, DF, Brazil | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Coordenação de Pesquisa. Brasília, DF, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Brasília. Faculdade de Medicina. Brasília, DF, Brazil | pt_BR |
| Subject | Yellow fever | pt_BR |
| Subject | vaccine administration | pt_BR |
