| Author | Nihei, Jorge Sadao | |
| Author | Cardillo, Fabíola | |
| Author | Santos, Washington Luis Courado dos | |
| Author | Carvalho, Lain Carlos Pontes de | |
| Author | Mengele Juniior, Jose Orivaldo | |
| Access date | 2015-04-06T17:18:17Z | |
| Available date | 2015-04-06T17:18:17Z | |
| Document date | 2014 | |
| Citation | NIHEI, J.; et al. Administration of a nondepleting anti-cd25 monoclonal antibody reduces disease severity in mice infected with trypanosoma cruzi. European Journal of Microbiology and Immunology, v.4, n.2, p. 128-137,2014. | pt_BR |
| ISSN | 2062509X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/9884 | |
| Language | eng | pt_BR |
| Publisher | Akadémiai Kiadó | en |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | Administration of a nondepleting anti-CD25 monoclonal antibody reduces disease severity in mice infected with Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | DOI:10.1556/eujmi.4.2014.2.6 | pt_BR |
| Abstract | The role of CD25+ regulatory T cells during the course of Trypanosoma cruzi infection has been previously analyzed, and the bulk
of results have shown a limited role for this T cell subpopulation. In this study, we have used an IgM, nondepleting monoclonal antibody
(mAb) aiming at blocking interleukin (IL)-2 activity on CD25+ T cells. The administration of this antibody 10 days before
infection increased the resistance of outbred Swiss mice to the Colombian strain of T. cruzi. Anti-CD25-treated mice had lower
parasitemia and augmented numbers of effector memory T cells. In addition, these animals showed higher numbers of splenic
T cells secreting IFN-γ and TNF-α, both cytokines described to be involved in the resistance to T. cruzi infection. The same treatment
also increased the numbers of splenic T cells that produced homeostatic and regulatory cytokines, such as IL-2 and IL-10, and
CD4+CD25+ T cells. The administration of nondepleting anti-CD25 mAb at the beginning of the chronic phase, when parasites
were cleared from the blood, halted the inflammatory process in the heart, without any signs of infection reactivation. These results
indicate that nondepleting anti-CD25 monoclonal antibodies may be useful to treat chronic Chagas’ disease. | en |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Muniz. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Muniz. Salvador,BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Faculdade de Medicina de Petrópolis - FMP/FASE. Petrópolis, RJ, Brasil. | |
| Subject | Trypanosoma cruzi | en |
| Subject | Interleukin 10 | en |
| Subject | Regulatory T cells | en |
| Subject | Anti-CD25 | en |
| Subject | Monoclonal antibody | en |
| Subject | Mice | en |
