| Author | Teixeira, S. L. M. | |
| Author | De Sá, N. B. R. | |
| Author | Campos, D. .P | |
| Author | Coelho, A. B. | |
| Author | Guimarães, M. L. | |
| Author | Leite, T. C. N. F. | |
| Author | Veloso, V. G. | |
| Author | Morgado, M. G. | |
| Access date | 2015-04-06T17:18:21Z | |
| Available date | 2015-04-06T17:18:21Z | |
| Document date | 2014 | |
| Citation | TEIXEIRA, S L M; et al. Association of the hla-b*52 allele with non-progression to aids in brazilian hiv-1-infected individuals. Genes and Immunity, v.15, n.4, p. 256-262,2014. | pt_BR |
| ISSN | 14664879 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/9895 | |
| Language | por | pt_BR |
| Rights | restricted access | |
| Title | Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals | pt_BR |
| Type | Article | |
| DOI | DOI:10.1038/gene.2014.14 | pt_BR |
| Abstract | Several human leukocyte antigen (HLA) class I alleles are associated with the susceptibility to human immunodeficiency virus-1
(HIV-1) infection and/or AIDS progression. Of these, the HLA-B alleles are considered the strongest genetic determinant of disease
outcome. We evaluated the influence of the HLA-B alleles on AIDS progression among HIV-1-positive individuals from Rio de Janeiro,
Brazil, who were categorized as rapid progressors (RPs), typical progressors (TPs) or long-term non-progressors (LTNPs). In this study,
significant differences in HLA-B allele frequencies were observed among the three progression groups for the B*48, B*49 and B*52
alleles. After controlling for other factors associated with AIDS progression, the presence of the B*52 allele was shown to be a
significant protective factor (hazard ratio (HR) 0.49 (95% confidence interval (CI) 0.27–0.90) Po0.03). Although no direct association
was observed between the presence of the B*27 or B*57 allele and the LTNP profile compared with the TP or RP groups, the adjusted
model confirmed that these alleles are protective factors against AIDS progression (HR 0.62 (95% CI 0.38–0.99) Po0.05), as previously
described. These data corroborate the existence of significant differences in HLA-B allele frequencies among the distinct AIDS
progression profiles and further elucidate the role of HLA alleles in the outcome of HIV infections in diverse populations. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas.Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas.Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas.Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | AIDS | en |
| DeCS | Síndrome de Imunodeficiência Adquirida | pt_BR |
| DeCS | Soropositividade para HIV | pt_BR |
| DeCS | Infecções por HIV | pt_BR |
| DeCS | Doenças Transmissíveis | pt_BR |
