| Author | Pereira, V. R. A. | |
| Author | Lorena, Virginia Maria Barros de | |
| Author | Silva, Ana Paula Galvão da | |
| Author | Coutinho, Eridan de Medeiros | |
| Author | Silva, Emilson Domingos da | |
| Author | Ferreira, Antonio Gomes Pinto | |
| Author | Miranda, P. | |
| Author | Krieger, Marco Aurélio | |
| Author | Goldenberg, Samuel | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Oliveira, R Correa | |
| Author | Gomes, Yara de Miranda | |
| Access date | 2015-04-10T14:27:34Z | |
| Available date | 2015-04-10T14:27:34Z | |
| Document date | 2004 | |
| Citation | PEREIRA, V. R. A. et al. Immunization with cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi stimulates a cellular immune response in mice. Parasitology, v. 129, n. Pt 5, p. 563-570, 2004. | pt_BR |
| ISSN | 0031-1820 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9949 | |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | open access | |
| Title | Immunization with cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi stimulates a cellular immune response in mice | pt_BR |
| Type | Article | |
| DOI | 10.1017/S0031182004006043 | |
| Abstract | In previous studies, we demonstrated that CRA and FRA recombinant proteins, used for diagnosis of Chagas' disease, elicited a humoral immune response in susceptible and resistant mice. To understand better the immune response to these proteins, we have evaluated, the cellular immune response in CRA- and in FRA-immunized BALB/c and C57BL/6 mice. A specific cellular lymphoproliferative response was observed in both strains of mice. Spleen cell cultures mainly from CRA-immunized C57BL/6 and FRA-immunized BALB/c mice produced high levels of IFN-y, indicating the induction of a Type 1 immune response. Regarding the T cell subsets, CD4+ T cells were the major source of IFN-y in CRA- and FRA-immunized mice. These results suggest that CRA and FRA are important immunogens in inducing a Type 1 immune response and that they may be considered as potential vaccine antigens. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Subject | Recombinant proteins | pt_BR |
| Subject | Immune cellular response | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| DeCS | Antígenos de Protozoários/imunologia | pt_BR |
| DeCS | Imunidade Celular | pt_BR |
| DeCS | Proteínas de Protozoários/imunologia | pt_BR |
| DeCS | Trypanosoma cruzi/imunologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Antígenos de Protozoários/administração & dosagem | pt_BR |
| DeCS | Citocinas/biossíntese | pt_BR |
| DeCS | Citometria de Fluxo | pt_BR |
| DeCS | Imunidade Celular/imunologia | pt_BR |
| DeCS | Imunização | pt_BR |
| DeCS | Ativação Linfocitária/imunologia | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Camundongos Endogâmicos BALB C | pt_BR |
