| Author | Cabello, Marina | |
| Author | Mendoza, Yaxelis | |
| Author | Bello, Gonzalo | |
| Access date | 2015-04-14T12:38:11Z | |
| Available date | 2015-04-14T12:38:11Z | |
| Document date | 2014 | |
| Citation | CABELLO, Mariza et al. Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region. Plos One, v.9, n.8, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/9972 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Subject in Portuguese | HIV-1 | pt_BR |
| Subject in Portuguese | Infecções por HIV | pt_BR |
| Subject in Portuguese | Caribe | pt_BR |
| Title | Spatiotemporal Dynamics of Dissemination of Non- Pandemic HIV-1 Subtype B Clades in the Caribbean Region | pt_BR |
| Type | Article | |
| Abstract | The Human immunodeficiency virus type-1 (HIV-1) epidemic in the Caribbean region is mostly driven by subtype B; but
information about the pattern of viral spread in this geographic region is scarce and different studies point to quite
divergent models of viral dissemination. In this study, we reconstructed the spatiotemporal and population dynamics of the
HIV-1 subtype B epidemic in the Caribbean. A total of 1,806 HIV-1 subtype B pol sequences collected from 17 different
Caribbean islands between 1996 and 2011 were analyzed together with sequences from the United States (n = 525) and
France (n = 340) included as control. Maximum Likelihood phylogenetic analyses revealed that HIV-1 subtype B infections in
the Caribbean are driven by dissemination of the pandemic clade (BPANDEMIC) responsible for most subtype B infections
across the world, and older non-pandemic lineages (BCAR) characteristics of the Caribbean region. The non-pandemic BCAR
strains account for .40% of HIV-1 infections in most Caribbean islands; with exception of Cuba and Puerto Rico. Bayesian
phylogeographic analyses indicate that BCAR strains probably arose in the island of Hispaniola (Haiti/Dominican Republic)
around the middle 1960s and were later disseminated to Trinidad and Tobago and to Jamaica between the late 1960s and
the early 1970s. In the following years, the BCAR strains were also disseminated from Hispaniola and Trinidad and Tobago to
other Lesser Antilles islands at multiple times. The BCAR clades circulating in Hispaniola, Jamaica and Trinidad and Tobago
appear to have experienced an initial phase of exponential growth, with mean estimated growth rates of 0.35–0.45 year21,
followed by a more recent stabilization since the middle 1990s. These results demonstrate that non-pandemic subtype B
lineages have been widely disseminated through the Caribbean since the late 1960s and account for an important fraction
of current HIV-1 infections in the region. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama / Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama.Department of Genetics and Molecular Biology. Panama City, Panama / INDICASAT-AIP, 219, City of Knowledge, Clayton, Panama City, Panama. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Hiv-1 | pt_BR |
| Subject | HIV Infections | pt_BR |
| Subject | Caribbean | pt_BR |
| Subject in Spanish | HIV-1 | pt_BR |
| Subject in Spanish | Infecciones por VIH | pt_BR |
| Subject in Spanish | Caribe | pt_BR |
