Author | Scorza, Breanna M | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Wilson, Mary E | |
Access date | 2017-07-11T13:42:16Z | |
Available date | 2017-07-11T13:42:16Z | |
Document date | 2017 | |
Citation | SCORZA, B. M.; CARVALHO FILHO, E. M.; WILSON, M. E. Cutaneous Manifestations of Human and Murine Leishmaniasis. International Journal of Molecular Sciences, v. 18, p. 1296, 2017. | pt_BR |
ISSN | 1661-6596 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20038 | |
Sponsorship | National Institutes of Health (NIH) grant AI076233, and by Merit Review grants 5I01BX001983-02 and 2I01BX000536 from the Department of Veterans’ Affairs (MEW). Studies were performed in part while B.M.S. was supported with funds from NIH T32 AI07511 | pt_BR |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Leishmaniose mucosa | pt_BR |
Subject in Portuguese | Leishmaniose difusa | pt_BR |
Subject in Portuguese | Leishmaniose disseminada | pt_BR |
Subject in Portuguese | Pele | pt_BR |
Subject in Portuguese | Kala-azar | pt_BR |
Subject in Portuguese | Imunologia | pt_BR |
Title | Cutaneous Manifestations of Human and Murine Leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/ijms18061296 | |
Abstract | The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection. | pt_BR |
Affilliation | University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA / University of Iowa. Department of Internal Medicine. Iowa City, IA, USA / University of Iowa. Department of Microbiology. Iowa City, IA, USA / Veterans’ Affairs Medical Center. Iowa City, IA, USA | pt_BR |
Subject | Leishmania | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | Mucosal leishmaniasis | pt_BR |
Subject | Diffuse leishmaniasis | pt_BR |
Subject | Disseminated leishmaniasis | pt_BR |
Subject | DTH-delayed type hypersensitivity skin test | pt_BR |
Subject | LST-Leishmania skin test | pt_BR |
Subject | Post-kala-azar dermal leishmaniasis | pt_BR |
Subject | Kala-azar | pt_BR |
Subject | Skin immunology | pt_BR |