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FUNCTIONAL POLYMORPHISMS IN IL13 ARE PROTECTIVE AGAINST HIGH SCHISTOSOMA MANSONI INFECTION INTENSITY IN A BRAZILIAN POPULATION
Author
Affilliation
The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil
The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America
The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil
The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America
The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America
Abstract
IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C.T) and rs20541 (or
R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been
thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for
genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil.
Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium
tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted
for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni
egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at
rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002).
Conclusions/Significance: The two functional variants in IL13 are protective against high S. mansoni egg counts. These
markers showed no evidence of association with tIgE levels, unlike tIgE levels previously studied in non-parasitized or atopic
study populations.
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