Author | Grant, Audrey V | |
Author | Araujo, Maria Ilma Andrade Santos | |
Author | Ponte, Eduardo Vieira | |
Author | Oliveira, Ricardo Riccio | |
Author | Gao, Peisong | |
Author | Cruz Filho, Alvaro Augusto Souza da | |
Author | Barnes, Kathleen C | |
Author | Beaty, Terri H | |
Access date | 2018-07-05T18:08:03Z | |
Available date | 2018-07-05T18:08:03Z | |
Document date | 2012 | |
Citation | GRANT, A. V. et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. Plos One, v. 7, n. 5, p. e35863, 2012. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27330 | |
Description | Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Glaxo-Smith-Kline under the project WE445 entitled ‘‘Immunogenetics of Schistosomiasis and Asthma,’’ and National Institutes of Health grant # AI050024. KCB | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Polimorfismo | pt_BR |
Subject in Portuguese | Schistosoma mansoni | pt_BR |
Subject in Portuguese | População | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0035863 | |
Abstract | IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C.T) and rs20541 (or
R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been
thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for
genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil.
Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium
tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted
for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni
egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at
rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002).
Conclusions/Significance: The two functional variants in IL13 are protective against high S. mansoni egg counts. These
markers showed no evidence of association with tIgE levels, unlike tIgE levels previously studied in non-parasitized or atopic
study populations. | pt_BR |
Affilliation | The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of America | pt_BR |
Affilliation | The Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America | pt_BR |
Subject | Polymorphisms | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | Populations | pt_BR |
Subject | Infection | pt_BR |
Subject | Humans | pt_BR |
Subject | Brazil | pt_BR |