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https://www.arca.fiocruz.br/handle/icict/2783
HDV GENOTYPES IN THE WESTERN BRAZILIAN AMAZON REGION: A PRELIMINARY REPORT
Virologia
Vírus Delta da Hepatite
Genética
Adolescente
Adulto
Brasil
Portador Sadio
Criança
Feminino
Genótipos
Humanos
Masculino
Hibridização de Ácido Nucleico
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Université Claude Bernard Lyon 1. INSERM Unit 271. Lyon, France
Universidade de Brasilia. Unidade de Medicina Tropical. Brasilia, DF, Brasil
Governo do Acre. Secretaria de Estado de Saúde. Rio Branco, AC, Brasil
Centro de Medicina Tropical. Porto Velho, RO, Brasil
Université Claude Bernard Lyon 1. INSERM Unit 271. Lyon, France
Universidade de Brasilia. Unidade de Medicina Tropical. Brasilia, DF, Brasil
Governo do Acre. Secretaria de Estado de Saúde. Rio Branco, AC, Brasil
Centro de Medicina Tropical. Porto Velho, RO, Brasil
Abstract
In Brazil, hepatitis delta virus (HDV) is only reported in Western Amazonia, where severe cases of acute and chronic HDV hepatitis have been described. The study area was chosen in the States of Acre and Rondonia where most cases of hepatitis B virus (HBV)/HDV are reported. From December 2003 to October 2004, 40 HBsAg carriers with anti-HDV IgM were selected. An epidemiologic questionnaire, including demographic and clinical/epidemiologic variables was filled out. HDV amplification and genotyping were performed. Genotype I was detected in 22 patients (55.0%), whereas genotype III was identified in 18 (45.0%). Patients who were infected with genotype I were older (45.1 +/- 17.8 years) than patients infected with genotype III (32.8 +/- 10.9 years; P = 0.01). No symptoms were reported by 21 (52.5%) patients. Otherwise, 19 (47.5%) had symptoms (fatigue, abdominal pain, weight loss, and decompensated liver disease) that motivated them to seek medical care. Genotype III carriers were more symptomatic, but no statistical significance was achieved. Our preliminary results show that HDV genotypes I and III are present in Brazilian Amazonia and that HDV genotype III is not limited to the Amerindian population.
DeCS
Hepatite BVirologia
Vírus Delta da Hepatite
Genética
Adolescente
Adulto
Brasil
Portador Sadio
Criança
Feminino
Genótipos
Humanos
Masculino
Hibridização de Ácido Nucleico
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