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Title: HDV genotypes in the Western Brazilian Amazon region: a preliminary report
Authors: Paraná, Raymundo
Kay, Alan
Molinet, Felix
Viana, Sebastião
Silva, Luciano Kalabric
Salcedo, Juan Miguel
Tavares Neto, José
Lobato, Cirley
Leite, Márcio Rios
Matteoni, Luciana
D' Oliveira Junior, Argemiro
Tauil, Pedro
Trépo, Christian
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Université Claude Bernard Lyon 1. INSERM Unit 271. Lyon, France
Universidade de Brasilia. Unidade de Medicina Tropical. Brasilia, DF, Brasil
Governo do Acre. Secretaria de Estado de Saúde. Rio Branco, AC, Brasil
Centro de Medicina Tropical. Porto Velho, RO, Brasil
Abstract: In Brazil, hepatitis delta virus (HDV) is only reported in Western Amazonia, where severe cases of acute and chronic HDV hepatitis have been described. The study area was chosen in the States of Acre and Rondonia where most cases of hepatitis B virus (HBV)/HDV are reported. From December 2003 to October 2004, 40 HBsAg carriers with anti-HDV IgM were selected. An epidemiologic questionnaire, including demographic and clinical/epidemiologic variables was filled out. HDV amplification and genotyping were performed. Genotype I was detected in 22 patients (55.0%), whereas genotype III was identified in 18 (45.0%). Patients who were infected with genotype I were older (45.1 +/- 17.8 years) than patients infected with genotype III (32.8 +/- 10.9 years; P = 0.01). No symptoms were reported by 21 (52.5%) patients. Otherwise, 19 (47.5%) had symptoms (fatigue, abdominal pain, weight loss, and decompensated liver disease) that motivated them to seek medical care. Genotype III carriers were more symptomatic, but no statistical significance was achieved. Our preliminary results show that HDV genotypes I and III are present in Brazilian Amazonia and that HDV genotype III is not limited to the Amerindian population.
Keywords: Hepatitis B
Western Amazon
keywords: Hepatite B
Amazônia Ocidental
DeCS: Hepatite B
Vírus Delta da Hepatite
Portador Sadio
Hibridização de Ácido Nucleico
Issue Date: 2006
Citation: PARANÁ, R. et al. HDV genotypes in the western brazilian amazon region: a preliminary report. The American Journal of Tropical Medicine and Hygiene, v.75, n.3, p.475-479, 2006.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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