Author | Bispo, Marcelle de Lima Ferreira | |
Author | Gonçalves, Raoni Schroeder Borges | |
Author | Lima, Camilo Henrique da Silva | |
Author | Cardoso, Laura Nogueira de Faria | |
Author | Lourenço, Maria Cristina Silva | |
Author | Souza, Marcus Vinícius Nora de | |
Access date | 2023-03-03T18:50:42Z | |
Available date | 2023-03-03T18:50:42Z | |
Document date | 2012 | |
Citation | BISPO, Marcelle de Lima Ferreira et al. Synthesis and antitubercular evaluation of N‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide derivatives. Journal of Heterocyclic Chemistry, v. 49, n. 6, p. 1317-1322, Nov. 2012. | en_US |
ISSN | 0022-152X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57243 | |
Language | eng | en_US |
Publisher | Hetero Corporation | en_US |
Rights | open access | en_US |
Title | Synthesis and Antitubercular Evaluation ofN‐Arylpyrazine andN,N′‐Alkyl‐diylpyrazine‐2‐carboxamide Derivatives | en_US |
Type | Article | en_US |
DOI | 10.1002/jhet.921 | |
Abstract | Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50–100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (>100 μg/mL). The obtained activities can be considered promising results, which characterizes these compounds as good start points to development of new antitubercular agents. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos (Farmanguinhos). Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Pyrazinamide (PZA) | en_US |
Subject | Mycobacterium tuberculosis H37Rv | en_US |
Subject | Antituberculosis drug PZA | en_US |