Author | Sagay, Atiene S. | |
Author | Hsieh, Szu-Chia | |
Author | Dai, Yu-Ching | |
Author | Chang, Charlotte Ajeong | |
Author | Ogwuche, Jerry | |
Author | Ige, Olukemi O. | |
Author | Kahansim, Makshwar L. | |
Author | Chaplin, Beth | |
Author | Imade, Godwin | |
Author | Elujoba, Michael | |
Author | Paul, Michael | |
Author | Hamel, Donald J. | |
Author | Furuya, Hideki | |
Author | Khouri, Ricardo | |
Author | Boaventura, Viviane Sampaio | |
Author | Moraes, Laíse de | |
Author | Kanki, Phyllis J. | |
Author | Wang, Wei-Kung | |
Access date | 2024-01-24T19:04:40Z | |
Available date | 2024-01-24T19:04:40Z | |
Document date | 2024 | |
Citation | SAGAY, Atiene S. et al. Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria. International Journal of Infectious Diseases, v. 139, p. 92-100, 2024. | en_US |
ISSN | 1201-9712 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62365 | |
Sponsorship | National Institute of Allergy and Infectious Diseases.
Fogarty Inter- national Center, National Institutes of Health.
Hawaii Community Foundation. | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Vírus Chikungunya | en_US |
Subject in Portuguese | Arbovírus | en_US |
Subject in Portuguese | Gravidez | en_US |
Subject in Portuguese | Transmissão perinatal | en_US |
Subject in Portuguese | Anormalidade congênita | en_US |
Subject in Portuguese | África | en_US |
Title | Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria | en_US |
Type | Article | en_US |
DOI | 10.1016/j.ijid.2023.11.036 | |
Abstract | Objectives: Chikungunya virus (CHIKV), a reemerging global public health concern, which causes acute febrile illness, rash, and arthralgia and may affect both mothers and infants during pregnancy. Mother-to-child transmission (MTCT) of CHIKV in Africa remains understudied. Methods: Our cohort study screened 1006 pregnant women with a Zika/dengue/CHIKV rapid test at two clinics in Nigeria between 2019 and 2022. Women who tested positive for the rapid test were followed through their pregnancy and their infants were observed for 6 months, with a subset tested by reverse transcription-polymerase chain reaction (RT-PCR) and neutralization, to investigate seropositivity rates and MTCT of CHIKV. Results: Of the 1006, 119 tested positive for CHIKV immunoglobulin (Ig)M, of which 36 underwent detailed laboratory tests. While none of the IgM reactive samples were RT-PCR positive, 14 symptomatic pregnant women were confirmed by CHIKV neutralization test. Twelve babies were followed with eight normal and four abnormal outcomes, including stillbirth, cleft lip/palate with microcephaly, preterm delivery, polydactyly with sepsis, and jaundice. CHIKV IgM testing identified three possible antepartum transmissions. Conclusion: In Nigeria, we found significant CHIKV infection in pregnancy and possible CHIKV antepartum transmission associated with birth abnormalities. | en_US |
Affilliation | Jos University Teaching Hospital. University of Jos. Jos, Nigeria. | en_US |
Affilliation | Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA. | en_US |
Affilliation | Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA. | en_US |
Affilliation | Department of Immunology and Infectious Diseases.Harvard T.H. Chan School of Public Health. Boston, USA. | en_US |
Affilliation | Our Lady of Apostles Hospital. Jos, Nigeria. | en_US |
Affilliation | Jos University Teaching Hospital. University of Jos. Jos, Nigeria. | en_US |
Affilliation | Jos University Teaching Hospital. University of Jos. Jos, Nigeria. | en_US |
Affilliation | Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA. | en_US |
Affilliation | Jos University Teaching Hospital. University of Jos. Jos, Nigeria. | en_US |
Affilliation | Our Lady of Apostles Hospital. Jos, Nigeria. | en_US |
Affilliation | Jos University Teaching Hospital. University of Jos. Jos, Nigeria. | en_US |
Affilliation | Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA. | en_US |
Affilliation | Department of Biomedical Science. Cedars-Sinai Medical Center. Los Angeles, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA. | en_US |
Affilliation | Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA. | en_US |
Subject | Chikungunya virus | en_US |
Subject | Arbovirus | en_US |
Subject | Pregnancy | en_US |
Subject | Perinatal transmission | en_US |
Subject | Congenital abnormality | en_US |
Subject | Africa | en_US |
DeCS | Vírus Chikungunya | en_US |
DeCS | Arbovírus | en_US |
DeCS | Gravidez | en_US |
DeCS | Transmissão Vertical de Doenças Infecciosas | en_US |
DeCS | Anormalidades congênitas | en_US |
DeCS | África | en_US |