| Author | Baptista, Abrahão Fontes | |
| Author | Goes, Bruno Teixeira | |
| Author | Menezes, Diego Silva | |
| Author | Gomes, Flavia Carvalho Alcantara | |
| Author | Cavalcanti, João Zugaib | |
| Author | Silva, Joice Stipursky | |
| Author | Gomes, Joyce R. S | |
| Author | Oliveira, Julia Teixeira | |
| Author | Santos, Marcos André Vannier dos | |
| Author | Martinez, Ana Maria Blanco | |
| Access date | 2015-04-15T12:59:17Z | |
| Available date | 2015-04-15T12:59:17Z | |
| Document date | 2009 | |
| Citation | BAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009. | pt_BR |
| ISSN | 1085-9489 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10000 | |
| Language | eng | pt_BR |
| Publisher | Woodland Publications | pt_BR |
| Rights | open access | pt_BR |
| Title | PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1111/j.1529-8027.2009.00240.x | |
| Abstract | The use of electromagnetic fields has been reported to enhance peripheralnerve regeneration. This study aimed to identify the effects of a prolonged protocolof low-frequency pulsed electromagnetic field (PEMF) on peripheral nerve regeneration.Thirty-four male Swiss mice (Mus musculus) were divided into PEMF (n= 17) and control(n= 17) groups. All animals underwent a unilateral sciatic-crush lesion, and the PEMF groupwas exposed to a 72-Hz, 2-G electromagnetic field for 30 min, five days a week, for threeweeks. Functional analysis was carried out weekly. After three weeks, the animals wereeuthanized, and histological, morphometric, oxidative stress, and TGF-β1 analyses wereperformed. Functional analysis showed no differences between the groups. Histologicalappearance was similar between PEMF and control nerves. Morphometric assessmentshowed that the PEMF nerves trended toward decreased regeneration. The levels of freeradicals were more pronounced in PEMF nerves, but were not associated with an increasein the content of the TGF-β1/Smad signaling pathway. Prolonged PEMF regimen leads todelayed histological peripheral nerve regeneration and increased oxidative stress but noloss of function recovery | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituo de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil / Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil | pt_BR |
| Affilliation | Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Electromagnetic fields | pt_BR |
| Subject | Mouse | pt_BR |
| Subject | Regeneration | pt_BR |
| Subject | Sciatic nerve lesion | pt_BR |
| DeCS | Terapia de Campo Magnético | pt_BR |
| DeCS | Regeneração Nervosa | pt_BR |
| DeCS | Nervo Isquiático | pt_BR |
| DeCS | Neuropatia Ciática | pt_BR |
| DeCS | Camundongos | pt_BR |
