Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10000
Title: PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion
Authors: Baptista, Abrahão Fontes
Goes, Bruno Teixeira
Menezes, Diego Silva
Gomes, Flavia Carvalho Alcantara
Cavalcanti, João Zugaib
Silva, Joice Stipursky
Gomes, Joyce R. S
Oliveira, Julia Teixeira
Santos, Marcos André Vannier dos
Martinez, Ana Maria Blanco
Affilliation: Universidade Federal da Bahia. Instituo de Ciências da Saúde. Departamento de Biomorfologia. Salvador, BA, Brasil / Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil
Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil
Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil
Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil
Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Unidade de Microscopia Eletrônica. Salvador, BA, Brasil
Universidade Federaldo Rio de Janeiro, Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil
Abstract: The use of electromagnetic fields has been reported to enhance peripheralnerve regeneration. This study aimed to identify the effects of a prolonged protocolof low-frequency pulsed electromagnetic field (PEMF) on peripheral nerve regeneration.Thirty-four male Swiss mice (Mus musculus) were divided into PEMF (n= 17) and control(n= 17) groups. All animals underwent a unilateral sciatic-crush lesion, and the PEMF groupwas exposed to a 72-Hz, 2-G electromagnetic field for 30 min, five days a week, for threeweeks. Functional analysis was carried out weekly. After three weeks, the animals wereeuthanized, and histological, morphometric, oxidative stress, and TGF-β1 analyses wereperformed. Functional analysis showed no differences between the groups. Histologicalappearance was similar between PEMF and control nerves. Morphometric assessmentshowed that the PEMF nerves trended toward decreased regeneration. The levels of freeradicals were more pronounced in PEMF nerves, but were not associated with an increasein the content of the TGF-β1/Smad signaling pathway. Prolonged PEMF regimen leads todelayed histological peripheral nerve regeneration and increased oxidative stress but noloss of function recovery
Keywords: Electromagnetic fields
Mouse
Regeneration
Sciatic nerve lesion
DeCS: Terapia de Campo Magnético
Regeneração Nervosa
Nervo Isquiático
Neuropatia Ciática
Camundongos
Issue Date: 2009
Publisher: Woodland Publications
Citation: BAPTISTA, A. F. et al. PEMF fails to enhance nerve regeneration after sciatic nerve crush lesion. Journal of the Peripheral Nervous system, v. 14, n. 4, p. 285-293, 2009.
DOI: 10.1111/j.1529-8027.2009.00240.x
ISSN: 1085-9489
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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