Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10009
Title: Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas disease
Other Titles: Resultados iniciais do transplante de células de medula óssea para o miocárdio de pacientes com insuficiência cardíaca de etiologia Chagásica
Authors: Vilas-Boas, Fábio
Feitosa, Gilson Soares
Soares, Milena Botelho Pereira
Mota, Augusto César de Andrade
Pinho Filho, Joel Alves
Almeida, Augusto José Gonçalves de
Andrade, Marcus Vinicius
Carvalho, Heitor Garcia de
Oliveira, Adriano Dourado de
Santos, Ricardo Ribeiro dos
Affilliation: Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: OBJECTIVE: To evaluate early effects of bone marrow cell transplantation to the myocardium of patients with heart failure (CHF) due to Chagas disease. METHODS: We studied 28 patients (mean age 52.2 +/- 9.9), of whom 24 were male. Despite optimized treatment, 25 patients were in NYHA class III and three patients, in NYHA class IV. The procedure consisted of aspiration of 50 mL of bone marrow, separation of the mononuclear fraction, and intracoronary injection. Effects on left ventricle ejection fraction (LVEF), distance walked in the six-minute walking test, quality-of-life, NYHA class, arrhythmogenic and biochemical parameters, were all evaluated. RESULTS: There were no complications directly related to the procedure. Baseline left ventricular ejection fraction was 20.1 +/- 6.8%, and 60 days after transplantation it increased to 23.0 +/- 9.0%, p = 0.02. Significant improvements were observed in the NYHA class (3.1 +/- 0.3 to 1.8 +/- 0.5; p < 0.0001); quality-of-life (50.9 +/- 11.7 to 21.8 +/- 13.4; p < 0.0001); and distance walked in six minutes (355 +/- 136 m to 443 +/- 110 m; p = 0,003). The number of ventricular premature beats in 24 hours tended to increase (5,322 +/- 4,977 to 7,441 +/- 7,955; p = 0,062), but without increase in ventricular tachycardia episodes (61 +/- 127 to 54 +/- 127; p = 0.27). CONCLUSION: Our data demonstrate for the first time that intracoronary injection of bone marrow mononuclear cells is feasible and suggest that it may be potentially safe and effective in patients with CHF due to Chagas disease
Keywords: Stem cell
Heart failure
Chagas disease
Cell therapy
Dilated cardiomyopathy
DeCS: Transplante de Medula Óssea/normas
Baixo Débito Cardíaco/cirurgia
Cardiomiopatia Chagásica/cirurgia
Baixo Débito Cardíaco/etiologia
Idoso
Adulto
Cardiomiopatia Chagásica/complicações
Feminino
Doença Crônica
Seguimentos
Humanos
Masculino
Meia-Idade
Sódio/análise
Transplante de Células-Tronco/normas
Células-Tronco/citologia
Issue Date: 2006
Publisher: Sociedade Brasileira de Cardiologia
Citation: VILAS-BOAS, F. et al. Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas disease. Arquivos Brasileiros de Cardiologia, v. 87, n. 2, p. 159-166, 2006.
ISSN: 0066-782X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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