Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10055
Title: The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics
Authors: Menna-Barreto, Rubem Figueiredo Sadok
Castro, Solange Lisboa
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Abstract: The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. are the causative agents of African trypanosomiasis, Chagas disease, and leishmaniasis, respectively. These diseases are considered to be neglected tropical illnesses that persist under conditions of poverty and are concentrated in impoverished populations in the developing world. Novel efficient and nontoxic drugs are urgently needed as substitutes for the currently limited chemotherapy. Trypanosomatids display a single mitochondrion with several peculiar features, such as the presence of different energetic and antioxidant enzymes and a specific arrangement ofmitochondrialDNA(kinetoplastDNA).Due tomitochondrial differences betweenmammals and trypanosomatids, this organelle is an excellent candidate for drug intervention. Additionally, during trypanosomatids’ life cycle, the shape and functional plasticity of their single mitochondrion undergo profound alterations, reflecting adaptation to different environments. In an uncoupling situation, the organelle produces high amounts of reactive oxygen species. However, these species role in parasite biology is still controversial, involving parasite death, cell signalling, or even proliferation. Novel perspectives on trypanosomatidtargeting chemotherapy could be developed based on better comprehension of mitochondrial oxidative regulation processes.
Keywords: Chagas Disease
Tripanosoma Cruzi
Pathogenic Trypanosomatids
keywords: Doença de Chagas
Tripanosoma Cruzi
Issue Date: 2014
Publisher: Hindawi Publishing Corporation
Citation: MENNA-BARRETO, Rubem Figueiredo Sadok et al. The Double-Edged Sword in Pathogenic Trypanosomatids: The Pivotal Role of Mitochondria in Oxidative Stress and Bioenergetics. BioMed Research International, v.2014, 14p, 2014.
DOI: /10.1155/2014/614014
ISSN: 2314-6133
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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