Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10078
Title: Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy.
Authors: Soares, Milena Botelho Pereira
Macambira, Simone Garcia
Carvalho, Antonio Carlos Campos de
Santos, Ricardo Ribeiro dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia de Laranjeiras. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Abstract: Nearly a century after its discovery, Chagas' disease, caused by the protozoan Trypanosoma cruzi, remains a major health problem in Latin America. Although efforts in transmission control have contributed to a decrease in the number of new cases, approximately a third of chronic Chagasic individuals have or will develop the symptomatic forms of the disease, mainly cardiomyopathy. Chagas' disease is a progressively debilitating disease, which, at the final stages, there are no currently available treatments other than heart transplantation. In this scenario, cellular therapy is being tested as an alternative for millions of patients with heart dysfunction due to Chagas' disease. In this article, we review the studies of cellular therapy in animal models and in patients with Chagasic cardiomyopathy and the possible mechanisms by which cellular therapy may act in this disease.
Keywords: Cardiomyopathy
Cellular therapy
Chagas disease
Fibrosis
Inflammation
Stem cells
DeCS: Cardiomiopatias/terapia
Transplante de Células/métodos
Transplante de Células/tendências
Doença de Chagas/terapia
Animais
Transplante de Medula Óssea/métodos
Cardiomiopatias/quimioterapia
Transplante de Células/patologia
Doença de Chagas/quimioterapia
Doença Crônica
Modelos Animais de Doenças
Humanos
Issue Date: 2007
Publisher: Future Medicine
Citation: SOARES, M. B. P. et al. Cellular therapy in Chagas' disease: potential applications in patients with chronic cardiomyopathy. Regenerative Medicine, v. 2, n. 3, p. 257-264, 2007.
DOI: 10.2217/17460751.2.3.257
ISSN: 1746-076X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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