Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10100
Title: Distantiae Transmission of Trypanosoma cruzi: A New Epidemiological Feature of Acute Chagas Disease in Brazil
Authors: Xavier, Samanta Cristina das Chagas
Roque, André Luiz Rodrigues
Bilac, Daniele
Araújo, Vitor Antônio Louzada de
Costa Neto, Sócrates Fraga da
Lorosa, Elias Seixas
Silva, Luiz Felipe Coutinho Ferreira da
Jansen, Ana Maria
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório Nacional e Internacional de Referência em Taxonomia de Triatomíneos. Rio de Janeiro, RJ, Brasil.
Instituto Militar de Engenharia. Laboratório de Cartografia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Abstract: Background: The new epidemiological scenario of orally transmitted Chagas disease that has emerged in Brazil, and mainly in the Amazon region, needs to be addressed with a new and systematic focus. Bele´m, the capital of Para´ state, reports the highest number of acute Chagas disease (ACD) cases associated with the consumption of ac¸aı´ juice. Methodology/Principal Findings: The wild and domestic enzootic transmission cycles of Trypanosoma cruzi were evaluated in the two locations (Jurunas and Val-de Ca˜es) that report the majority of the autochthonous cases of ACD in Bele´m city. Moreover, we evaluated the enzootic cycle on the three islands that provide most of the ac¸aı´ fruit that is consumed in these localities. We employed parasitological and serological tests throughout to evaluate infectivity competence and exposure to T. cruzi. In Val-de-Ca˜es, no wild mammal presented positive parasitological tests, and 56% seroprevalence was observed, with low serological titers. Three of 14 triatomines were found to be infected (TcI). This unexpected epidemiological picture does not explain the high number of autochthonous ACD cases. In Jurunas, the cases of ACD could not be autochthonous because of the absence of any enzootic cycle of T. cruzi. In contrast, in the 3 island areas from which the ac¸aı´ fruit originates, 66.7% of wild mammals and two dogs displayed positive hemocultures, and 15.6% of triatomines were found to be infected by T. cruzi. Genotyping by mini-exon gene and PCR-RFLP (1f8/Akw21I) targeting revealed that the mammals and triatomines from the islands harbored TcI and Trypanosoma rangeli in single and mixed infections. Conclusion/Significance: These findings show that cases of Chagas disease in the urban area of Bele´m may be derived from infected triatomines coming together with the ac¸aı´ fruits from distant islands. We term this new epidemiological feature of Chagas disease as ‘‘Distantiae transmission’’.
Keywords: Chagas disease
Brazil
Trypanosoma cruzi
keywords: Doença de Chagas
Brasil
Trypanosoma cruzi
Issue Date: 2014
Publisher: Plos One
Citation: XAVIER, Samanta Cristina das Chagas et al. Distantiae Transmission of Trypanosoma cruzi: A New Epidemiological Feature of Acute Chagas Disease in Brazil. PLoS Negl Trop Dis, v.8, n.5, 9p. 2014.
DOI: 10.1371/journal.pntd.0002878
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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