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Aug. 2015
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- ICTB - Artigos de Periódicos [40]
- IOC - Artigos de Periódicos [12730]
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HEMATOLOGICAL AND HISTOPATHOLOGICAL CHANGES IN RATTUS NORVEGICUS (WISTAR) EXPERIMENTALLY INFECTED BY ANGIOSTRONGYLUS CANTONENSIS (CHEN, 1935)
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Abstract
Eosinophilicmeningitis caused by Angiostrongylus cantonensis is a zoonosis endemic to Southeast Asia and the Pacific
islands. It is considered an emerging disease because it has been expanding both geographically and in terms
of the range of hosts. In South America, the first caseswere reported in Brazil andwere attributed to eating infected
snails. In this study, 70 adult females of Rattus norvegicus (Wistar) were used to evaluate hematology, blood
gases, cardiac markers and lung histopathology changes caused by this parasite. Of them, 60 were individually
infected by orogastric gavagewith 100 L3 larvae and 10 uninfected animals formed the control group. The results
obtained demonstrate that infection caused by A. cantonensis in R. norvegicus promotes significant hematological
changes induced in the vertebrate host, manifested mainly in the form of regenerative anemia, thrombocytopenia
and eosinophilia. Additionally, histopathological changes in the lung parenchyma demonstrated in rodents
reveal the occurrence of areas of necrosis and extensive fibrosis, being directly related to the development of cellular
hypoxia and enzyme cardiac changes. This study can contribute to a better understanding of the relationship
between A. cantonensis and R. norvegicus.
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