| Author | Evan-Osses, Ingrid | |
| Author | Mojoli, Andres | |
| Author | Beltrame, Marcia Holsbach | |
| Author | Costa, Denise Endo da | |
| Author | Rocha, Wanderson Duarte da | |
| Author | Velavan, Thirumalaisamy O | |
| Author | Reason, Iara de Messias | |
| Author | Ramirez, Marcel Ivan | |
| Access date | 2015-05-04T17:07:27Z | |
| Available date | 2015-05-04T17:07:27Z | |
| Document date | 2014 | |
| Citation | EVAN-OSSES, Ingrid et al. Differential ability to resist to complement lysis and invade host cells mediated by MBL in R4 and 860 strains of Trypanosoma cruzi. FEBS Letters v.588, n.6, p.956–961, 2014. | pt_BR |
| ISSN | 0014-5793 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10193 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Title | Differential ability to resist to complement lysis and invade host cells mediated by MBL in R4 and 860 strains of Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.febslet.2014.01.054 | pt_BR |
| Abstract | To produce an infection Trypanosoma cruzi must evade lysis by the complement system. During early stages of infection, the lectin pathway plays an important role in host defense and can be activated by binding of mannan-binding lectin (MBL) to carbohydrates on the surface of pathogens. We hypothesized that MBL has a dual role during parasite-host cell interaction as lectin complement pathway activator and as binding molecule to invade the host cell. We used two polarized strains of T. cruzi, R4 (susceptible) and 860 (resistant) strains, to investigate the role of MBL in complement-mediated lysis. Interestingly R4, but not 860 metacyclic strain, markedly increases the invasion of host cells, suggesting that MBL drives the invasion process while the parasite deactivates the Lectin complement pathway. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Patologia Médica. Laboratório de Imunopatologia Molecular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Patologia Médica. Laboratório de Imunopatologia Molecular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Laboratório de Genômica Funcional de Parasitos. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | University of Tübingen. Instituto of Tropical Medicine. Tübingen, Germany. | pt_BR |
| Affilliation | Universidade Federal do Paraná. Departamento de Patologia Médica. Laboratório de Imunopatologia Molecular. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Mannan binding lectin | pt_BR |
| Subject | Complement system | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Inate immunity | pt_BR |
| Subject | Parasite–host cell interaction | pt_BR |
| Subject in Spanish | Enfermedad de Chagas | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
