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Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- IOC - Artigos de Periódicos [12969]
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DIFFERENTIAL ABILITY TO RESIST TO COMPLEMENT LYSIS AND INVADE HOST CELLS MEDIATED BY MBL IN R4 AND 860 STRAINS OF TRYPANOSOMA CRUZI
Complement system
Chagas disease
Inate immunity
Parasite–host cell interaction
Author
Affilliation
Abstract
To produce an infection Trypanosoma cruzi must evade lysis by the complement system. During early stages of infection, the lectin pathway plays an important role in host defense and can be activated by binding of mannan-binding lectin (MBL) to carbohydrates on the surface of pathogens. We hypothesized that MBL has a dual role during parasite-host cell interaction as lectin complement pathway activator and as binding molecule to invade the host cell. We used two polarized strains of T. cruzi, R4 (susceptible) and 860 (resistant) strains, to investigate the role of MBL in complement-mediated lysis. Interestingly R4, but not 860 metacyclic strain, markedly increases the invasion of host cells, suggesting that MBL drives the invasion process while the parasite deactivates the Lectin complement pathway.
Keywords in Portuguese
Doença de ChagasKeywords
Mannan binding lectinComplement system
Chagas disease
Inate immunity
Parasite–host cell interaction
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