Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10214
Title: Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension
Authors: Spinasse, Lizania Borges
Santos, Adalberto Rezende
Suffys, Philip Noel
Muxfeldt, Elizabeth Silaid
Salles, Gil Fernando
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada em Micobactérias . Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Escola de Medicina. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Escola de Medicina. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.
Abstract: Aim: Hydralazine, a vasodilator used in resistant hypertension (RH) treatment is metabolized by an acetylation reaction mediated by N-acetyltransferase 2, the activity of which depends on NAT2 polymorphisms. Our aim was to evaluate whether different acetylation phenotypes influenced the antihypertensive effect of hydralazine in patients with RH. Patients & methods: DNA samples from 169 RH patients using hydralazine were genotyped by sequencing the NAT2 coding region, and acetylation phenotypes were defined. Results: Sixty-five patients (38.5%) were intermediate, 60 (35.5%) slow and 21 (12.4%) fast acetylators. Twenty-three (13.6%) patients were indeterminate. Upon association analysis, only slow acetylators had significant blood pressure reductions after hydralazine use, with mean 24-h systolic and diastolic blood pressure reductions of 9.2 and 5.5 mmHg. Four patients presented hydralazine adverse effects resulting in drug withdrawal, three of them were slow acetylators. Conclusion: The slow acetylation phenotype, determined by polymorphisms within NAT2, influenced both the antihypertensive and adverse effects of hydralazine in RH.
Keywords: Brazilian population
Hydralazine
NAT2 polymorphism
Resistant hypertension
SNP
Keywords in spanish: Hidralazina
Hipertensión
Brasil
Población
keywords: Hidralazina
Hipertensão
Brasil
População
DeCS: Ciências Biológicas
Hidralazina
Issue Date: 2014
Publisher: Future Medicine Ltd
Citation: SPINASSE, Lizania Borges et al. Different phenotypes of the NAT2 gene influences hydralazine antihypertensive response in patients with resistant hypertension. Pharmacogenomics, v.15, n.2, p.169-178, 2014.
DOI: 10.2217/pgs.13.202
ISSN: 1462-2416
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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