Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10262
Title: Structural and Molecular Modeling Features of P2X Receptors
Authors: Alves, Luiz Anastácio
Silva, João Hermínio Martins da
Ferreira, Dinarte Neto Moreira
Fidalgo Neto, Antonio Augusto
Teixeira, Pedro Celso Nogueira
Souza, Cristina Alves Magalhães de
Caffarena, Ernesto Raúl
Freitas, Mônica Santos de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Fortaleza, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
Abstract: Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.
Keywords: P2X7 receptor
Ion channel activity
Patch-clamp
Issue Date: 2014
Publisher: MDPI
Citation: ALVES, Luiz Anastacio et al. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences, n.15, p.4531-4549, 2014.
DOI: 10.3390/ijms15034531
ISSN: 1422-0067
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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