Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10451
Title: Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells
Authors: Xavier, Flavia Calo de Aquino
Prates, Alisio Alves
Gurgel, Clarissa Araújo Silva
Souza, Tulio Geraldo de
Andrade, Rodrigo Guimarães
Ramos, Eduardo Antônio Gonçalves
Ramalho, Luciana Maria Pedreira
Santos, Jean Nunes dos
Affilliation: Federal University of Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Bom Jesus da Lapa, BA, Brasil
Hospital Aliança. Salvador, BA, Brasil
Hospital Português. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Abstract: Lichen sclerosus (LS) is a mucocutaneous disease with uncommon oral involvement. The etiology is not yet well understood, but LS has been associated with autoimmune, genetic, and immunological factors. We report a 47-year-old man with LS that exhibited an asymptomatic white plaque with red patches on the maxillary alveolar mucosa extending to the labial mucosa. He had no other skin disease. Positive immunostaining for tenascin and scarcity of fibronectin suggested extracellular matrix reorganization. Elastin immunostaining indicated a reduction of elastic fibers. Immunoexpression of collagen IV in blood vessels and its absence in the epithelial basement membrane, together with diffuse MMP-9 immunoexpression, suggested altered proteolytic activity. Mast cell staining bordering areas of sclerosis indicated a possible role in the synthesis of collagen. IgG4 positivity in plasma cells suggested a role in the fibrogenesis. This is an unusual presentation of oral LS and we discuss immunohistochemical findings regarding cellular and extracellular matrix components
Keywords: Lichen sclerosus et atrophicus
Oral cavity
Immunohistochemistry
Metalloprotein
IgG4
Issue Date: 2014
Publisher: University of California, Davis
Citation: XAVIER, f. c. a. et al. Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells. Dermatology Online Journal. v. 20, n. 9, 2014.
ISSN: 1087-2108
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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