Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10489
Title: Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis.
Authors: Araújo, Alan M
Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Ribeiro, Guilherme de Sousa
Hagan, José Edward
Araujo, Guilherme C
Damião, Alcinéia Oliveira
Couto, Nicolli S
Ko, Albert Icksang
Dutra, Alberto Noronha
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil
Yale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Yale University. New Haven. CT / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Abstract: Leptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stress
DeCS: Lesão Renal Aguda/sangue
Glutationa/sangue
Leptospirose/sangue
Estresse Oxidativo
Espécies de Oxigênio Reativas/sangue
Trombocitopenia/sangue
Adolescente
Adulto
Marcadores Biológicos/sangue
Estudos de Casos e Controles
Estudos de Coortes
Creatinina/sangue
Feminino
Humanos
Masculino
Meia-Idade
Potássio/sangue
Índice de Gravidade de Doença
Adulto Jovem
Issue Date: 2014
Publisher: American Society of Tropical Medicine and Hygiene
Citation: ARAÚJO, A. M. et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. American Journal of Tropical Medicine and Hygiene, v. 90, n. 4, p. 719-723, 2014.
DOI: 10.4269/ajtmh.13-0667
ISSN: 1476-1645
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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