Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10574
Title: Antitumor Properties of the Leaf Essential Oil of Zornia brasiliensis
Authors: Costa, Emmanoel Vilaça
Menezes, Leociley Rocha Alencar
Rocha, Suellen L. A
Baliza, Ingrid Rayssa Souza
Dias, Rosane Borges
Rocha, Clarissa Araujo Gurgel
Soares, Milena Botelho Pereira
Bezerra, Daniel Pereira
Affilliation: Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil / Federal University of Sergipe. Department of Chemistry. Itabaiana, SE, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Zornia brasiliensis, popularly known as “urinária”, “urinana”, and “carrapicho”, is a medicinal plant used in Brazilian northeast folk medicine as a diuretic and against venereal diseases. The aim of this study was to investigate the chemical composition and antitumor potential of the leaf essential oil of Z. brasiliensis. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed by GC‑MS and GC‑FID. Its composition was characterized by the presence of trans-nerolidol, germacrene D, trans-caryophyllene, α-humulene, and farnesene as major constituents. In vitro cytotoxicity of the essential oil and some of its major constituents (trans-nerolidol, trans-caryophyllene, and α-humulene) was evaluated for tumor cell lines from different histotypes using the Alamar blue assay. The essential oil, but not the constituents tested, presented promising cytotoxicity. Furthermore, mice inoculated with B16-F10 mouse melanoma were used to confirm its in vivo effectiveness. An in vivo antitumor study showed tumor growth inhibition rates of 1.68–38.61% (50 and 100 mg/kg, respectively). In conclusion, the leaf essential oil of Z. brasiliensis presents trans-nerolidol, germacrene D, trans-caryophyllene, α-humulene, and farnesene as major constituents and is able to inhibit cell proliferation in cultures as well as in tumor growth in mice.
Keywords: Zornia brasiliensis
Fabaceae
Essential oil
Cytotoxicity
B16‑F10
Issue Date: 2014
Publisher: Verlag KG Stuttgart
Citation: COSTA, E. V. et al. Antitumor properties of the leaf essential oil of Zornia brasiliensis. Planta Médica, 2015
DOI: 10.1055/s-0035-1545842
ISSN: 0032‑0943
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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