| Author | Cardoso, Cristiane Wanderley | |
| Author | Ribeiro, Guilherme de Sousa | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Flannery, Brendan | |
| Author | Reis, Joice Neves | |
| Access date | 2015-05-29T18:31:22Z | |
| Available date | 2015-05-29T18:31:22Z | |
| Document date | 2015 | |
| Citation | CARDOSO, C. W. et al. Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: a case-control study. PloS One, v. 10, n.4, p. e0123734, 2015. | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10587 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença meningococica | pt_BR |
| Subject in Portuguese | Vacinas meningococica | pt_BR |
| Subject in Portuguese | Epidemia | pt_BR |
| Subject in Portuguese | Vigilância | pt_BR |
| Subject in Portuguese | Masculino | pt_BR |
| Subject in Portuguese | Feminino | pt_BR |
| Subject in Portuguese | Controle | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0123734 | |
| Abstract | During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010,
Brazil, the state government initiated mass vaccination targeting two age groups with high
attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal
serogroup C conjugate vaccines were administered. We performed a casecontrol
study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons
for non-vaccination.
Methods and Findings
Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal
C (MenC) disease during 2010. Information on MenC vaccination was obtained from
case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness
was estimated based on the exact odds ratios obtained by conditional logistic regression
analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease
among patients <5 and 10–24 years of age 50 were included in the study and matched with
240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased
from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case
patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with
cases from the period afterMenC vaccination, had received at least one MenC vaccine dose.
Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%.
Conclusions
MenC vaccines administered during the meningococcal epidemic were highly effective,
suggesting that rapid vaccine uptake through campaigns contributed to control of
meningococcal disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. | pt_BR |
| Affilliation | Pan American Health Organization. Brasília, DF, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, Brasil | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
