Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10587
Title: Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
Authors: Cardoso, Cristiane Wanderley
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
Flannery, Brendan
Reis, Joice Neves
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia.
Pan American Health Organization. Brasília, DF, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, Brasil
Abstract: During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease.
keywords: Doença meningococica
Vacinas meningococica
Epidemia
Vigilância
Masculino
Feminino
Controle
Brasil
Issue Date: 2015
Publisher: Public Library of Science
Citation: CARDOSO, C. W. et al. Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: a case-control study. PloS One, v. 10, n.4, p. e0123734, 2015.
DOI: 10.1371/journal.pone.0123734
ISSN: 1932-6203
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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