| Author | Guercio, G. D | |
| Author | Bevictori, L | |
| Author | Lopes, C. Vargas | |
| Author | Madeira, C | |
| Author | Oliveira, A | |
| Author | Carvalho, V. F | |
| Author | d`Avila, J. C | |
| Author | Panizzutti, R | |
| Access date | 2015-06-01T19:34:27Z | |
| Available date | 2015-06-01T19:34:27Z | |
| Document date | 2014 | |
| Citation | GUERCIO, G. D. et al. D-serine prevents cognitive deficits induced by acute stress. Neuropharmacology, v.86, p.1-8, 2014. | pt_BR |
| ISSN | 0028-3908 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10628 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Estresse | pt_BR |
| Title | D-serine prevents cognitive deficits induced by acute stress | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.neuropharm.2014.06.021 | pt_BR |
| Abstract | Increasing evidence indicates that acute stress disrupts cognitive functions mediated by glutamate-
NMDA receptors, although the mechanisms are not fully understood. Here we investigated whether Dserine
and glycine, the endogenous co-agonists of the NMDA receptor, are regulated by acute stress. We
studied the biochemical and behavioral effects of acute restraint stress in C57BL/6 mice. Acute restraint
stress decreased D-serine levels in the prefrontal cortex and glycine levels in the hippocampus. Behaviorally,
acute stress impaired memory consolidation in the object recognition task and prepulse inhibition
of the startle response. Importantly, D-serine administration (1 g/kg, i.p.) prevented both stressinduced
impairments. Taken together, our results show for the first time an interplay between stress
and D-serine and warrant further research on the role of D-serine in stress-related disorders. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | D-serine | pt_BR |
| Subject | Stress | pt_BR |
| Subject | NMDA receptor | pt_BR |
| Subject | Prepulse inhibition | pt_BR |
| Subject | Serine racemase | pt_BR |
| Subject | Object recognition task | pt_BR |
| Subject | Cognition | pt_BR |
| DeCS | Inibição Pré-Pulso | pt_BR |
| DeCS | Cognição | pt_BR |
| DeCS | Serina | pt_BR |
