Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10631
Title: Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil
Authors: Sánchez-Arcila, Juan Camilo
Silva, Daiana de Souza Perce da
Vasconcelos, Mariana Pinheiro Alves
Silva, Rodrigo Nunes Rodrigues da
Pereira, Virginia Araujo
Aprígio, Cesarino Junior Lima
Lima, Cleoni Alves Mendes
Fonseca, Bruna de Paula Fonseca e
Bank, Dalma Maria
Lima Junior, Josué da Costa
Ferreira, Joseli Oliveira
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.
Instituto de Infectologia Emílio Ribas. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
Agência de Vigilância em Saúde da Secretaria de Estado da Saúde (AGEVISA). Porto Velho, RO, Brasil.
Universidade Federal de Rondônia. Centro Interdepartamental de Biologia Experimental e Biotecnologia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
Abstract: In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma frominfected individualswith concurrentmalaria and intestinal parasites to individualswith eithermalaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18%coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-𝛼, IL-10, and CRPand lowlevels of IL-17Apredominantlywith individuals with malaria alone and coinfected individuals. In contrast, lowlevels of almost all inflammatory mediatorswere associated predominantlywith individuals uninfectedwhile increased levels of IL-17Awere associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivax
Keywords: Malaria
Amazon region
Intestinal parasites
keywords: Parasitos
Malária
Região Amazônica
Issue Date: 2014
Publisher: Hindawi Publishing Corporation
Citation: SÀNCHEZ-ARCILA, Juan Camilo et al. Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil. Mediators of Inflamation, v.2014, Article ID857245, 12p, 2014.
DOI: 10.1155/2014/857245
ISSN: 1466-1861
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos
IOC - Artigos de Periódicos

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