Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10685
Title: Cytotoxicity of Piperamides Towards Aedes aegypti (Diptera: Culicidae)
Authors: Maleck, Marise
Ferreira, Bruna
Santos-Mallet, Jacenir R.
Guimarães, Anthony
Kato, Massuo
Affilliation: Centro de Ciências da Saúde. Laboratório de Insetos Vetores. Mestrado ProÞssional em Ciências Ambientais. Vassouras, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Diptera. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Leishmanioses. Setor de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Diptera. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Instituto de Química. Laboratório de Produtos Naturais. São Paulo< SP, Brasil.
Abstract: The effectiveness of the amides piplartine and piperlonguminine isolated from Piper species for controlling L3 and L4 of Aedes aegypti (L.) was assessed through bioassays at concentrations ranging from 1 to 300 g/ml. Piplartine reduced the mosquito development period and caused larval mortality only at concentrations 100 g/ml, whereas piperlonguminine resulted in an extended period of mosquito development (10 g/ml) and caused 100% larval mortality (30 g/ml) within 24 h. The toxicity and cytotoxic effects of piperlonguminine on epithelial cells of the digestive system of Ae. aegypti were viewed using transmission electron microscopy, which indicated vacuolization of cytoplasm, mitochondrial swelling and leaking of nuclear material. Piperlonguminine was the more effective amide, showing toxic activity with LD50 of 12 g/ml against the larvae of Ae. aegypti.
Keywords: Cytotoxicity
Culicidae
Larvicide
Piperamide
Aedes aegypti
keywords: Citotoxicidade
Aedes
DeCS: Culicidae
Issue Date: 2014
Publisher: BioOne
Citation: MALECK, Marise et al. Cytotoxicity of Piperamides Towards Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology, v.51, n.2, p.458-463. 2014.
DOI: 10.1603/ME13069
ISSN: 1938-2928
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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