Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10736
Title: Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
Authors: Bittencourt, Achilea Candida Lisboa
Barbosa, Helenemarie Schaer
Vieira, Maria das Graças
Vallve, Maria de Lourdes Farre
Affilliation: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Abstract: Background. Adult T-cell leukemia/lymphoma (ATL) is a severe disease caused by HTLV-I. This paper describes the clinicopathological and immunohistochemical findings of 52 cases of ATL with skin involvement and investigates whether there is any relationship between median survival time (MST) and histological patterns, primary cutaneous involvement and CD8 positivity. Material and methods. All cases were HTLV-I and HIV- and were clinically classified. HTLV-I proviral integration was investigated in atypical cases. Immunohistochemistry was performed using CD3, CD4, CD5, CD7, CD8, CD20, CD25, CD30 and CD45RO markers. Ki-67 was used to evaluate the proliferative index. Results. Twentyseven cases were primary, while 25 were secondary. Monoclonal viral integration was demonstrated in all atypical cases. Patterns resembling mycosis fungoides (MF) were found in 19 cases and anaplastic large-cell lymphoma (ALCL) in two cases. Fifteen cases had an atypical immunophenotype and expressed CD8. Primary cutaneous ATL had a longer MST (48 months) than the secondary cutaneous ATL (7 months) and the difference was statistically significant, but no statistically significant difference was found between the MST of CD8-positive and negative cases. Conclusions. It is important to differentiate between primary and secondary cutaneous ATL and classify the cases histologically in order to better evaluate the prognosis. The two forms of primary cutaneous ATL, primary cutaneous smoldering and primary cutaneous tumoral (PCT), should also be identified. The smoldering type presented a longer survival (58 months) and histological aspects suggestive of better prognosis in contrast to the PCT type that had a shorter survival (20 months) and histological characteristics suggestive of worse outcome.
DeCS: Antígenos CD8/análise
Linfócitos T CD8-Positivos/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
Adolescente
Adulto
Idoso
Idoso de 80 anos ou mais
Antígenos CD/análise
Linfócitos T CD8-Positivos/imunologia
Proliferação de Células
Criança
Feminino
Humanos
Imuno-Histoquímica
Imunofenotipagem
Leucemia-Linfoma de Células T do Adulto/imunologia
Neoplasias Cutâneas/imunologia
Análise de Sobrevida
Issue Date: 2009
Publisher: Informa Healthcare
Citation: BITTENCOURT, A. C.L. et al. Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases. Acta Oncologica, v. 48, n. 4, p. 598-604, 2009.
DOI: 10.1080/02841860802657235
ISSN: 1651-226X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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