Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10782
Title: Infective dermatitis associated with human T-cell lymphotropic virus type 1: evaluation of 42 cases observed in Bahia, Brazil.
Authors: Oliveira, Maria de Fátima Santos Paim de
Fatal, Priscila Lima
Primo, Janeusa Rita Leite
Silva, José Lucas Sena da
Batista, Everton da Silva
Vallve, Maria de Lourdes Farre
Bittencourt, Achilea Candida Lisboa
Affilliation: Universidade Federal da Bahia. Complexo Hospital Universitário Prof. Edgard Santos. Serviço de Dermatologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Complexo Hospital Universitário Prof. Edgard Santos. Serviço de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Complexo Hospital Universitário Prof. Edgard Santos. Serviço de Neurologia Pediátrica. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
Universidade Federal da Bahia. Complexo Hospital Universitário Prof. Edgard Santos. Serviço de Patologia. Salvador, BA, Brasil
Abstract: Background. Infective dermatitis associated with human T-cell lymphotropic virus type 1 (HTLV-1; IDH) is a chronic recurrent eczema affecting HTLV-1–infected children. The epidemiological and dermatological characteristics of IDH are described, and their principal diagnostic criteria are reevaluated. Methods. Forty-two patients were included: 40 patients serologically positive for HTLV-1 and 2 seronegative patients who tested positive in polymerase chain reaction (PCR) assays. Results. The mean age at onset of the disease was 2.6 ± 2.4 years (range, 2 months–11 years). The mean duration of breast-feeding was 24.2 months. The lesions were erythematous, scaly, and crusted, always affecting the scalp and retroauricular regions. Crusting of the nostrils was observed in 64.3% of the patients. Of the 36 patients followed up, 23 had the active disease. The age at which IDH disappeared in the others was 10–20 years. Conclusions. The onset of IDH may occur earlier than reported in the literature. The scalp and retroauricular regions are always affected, and lesions are invariably present in ≥3 areas. Crusting of the nostrils cannot be considered an obligatory factor for the diagnosis of IDH. The recurring nature of IDH was a characteristic found in all cases. Patients with classic IDH lesions who are serologically negative should be investigated by PCR. Therefore, the indispensable criteria for diagnosis are (1) presence of erythematous-scaly, exudative, and crusted lesions involving ≥3 areas, including the scalp and retroauricular regions; (2) recurring nature of the lesions; and (3) a finding of HTLV-1 infection by serology or molecular biology.
DeCS: Eczema/epidemiologia
Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Dermatopatias Infecciosas/epidemiologia
Adolescente
Brasil/epidemiologia
Criança
Pré-Escolar
Técnicas de Laboratório Clínico/métodos
Eczema/diagnóstico
Feminino
Infecções por HTLV-I/virologia
Humanos
Lactente
Masculino
Pescoço/patologia
Nariz/patologia
Reação em Cadeia da Polimerase/métodos
Recidiva
Couro Cabeludo/patologia
Dermatopatias Infecciosas/diagnóstico
Issue Date: 2012
Publisher: Oxford University Press
Citation: OLIVEIRA, M. F. S. P. et al. Infective dermatitis associated with human T-cell lymphotropic virus type 1: evaluation of 42 cases observed in Bahia, Brazil. Clinical of Infectious Diseases, v. 54, n. 12, p. 1714-1719, 2012.
DOI: 10.1093/cid/cis273
ISSN: 1058-4838
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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