Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10784
Title: Adult T-cell leukemia/lymphoma in Bahia, Brazil: analysis of prognostic factors in a group of 70 patients.
Authors: Bittencourt, Achilea Candida Lisboa
Vieira, Maria da Graças
Alves, Carlos Roberto Brites
Vallve, Maria de Lourdes Farre
Barbosa, Helenemarie Schaer
Affilliation: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Medicina Interna. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Abstract: The purpose of this study was to evaluate whether subdivision of adult T-cell leukemia/lymphoma (ATL) on the basis of clinical types, skin involvement, histologic features, cell size, and proliferative index (PI) was clinically relevant. Skin lesions were present in 47 cases (67%). Five cases were classified as primary cutaneous tumoral (PCT) type not included in the Shimoyama classification and characterized by skin tumors and absence of systemic involvement, lymphocytosis, and hypercalcemia. Mortality was high (61/70 [87%]). The overall median survival time (MST) was 12 months. The following variables were adversely related to survival: acute, lymphoma, and PCT types; absence of skin lesions; large cells; and PI more than 18%. The longer MST observed in cases with skin lesions was probably due to prolonged survival of the smoldering type (58 months). The MST of the PCT type (21 months) was shorter than that of the smoldering type, confirming the importance of clearly defining these 2 types of ATL
Keywords: Adult T-cell leukemia/lymphoma
Mature T-cell leukemia/lymphoma
Cutaneous T-cell lymphoma
HTLV-I infection
Myelopathy associated with HTLV-I/tropical spastic paraparesis;
HAM/TSP
DeCS: Leucemia-Linfoma de Células T do Adulto/diagnóstico
Linfoma de Células T/diagnóstico
Adolescente
Adulto
Idoso
Idoso de 80 anos ou mais
Brasil/epidemiologia
Criança
Feminino
Humanos
Leucemia-Linfoma de Células T do Adulto/classificação
Linfoma de Células T/classificação
Masculino
Meia-Idade
Prognostico
Linfoma de Células T/mortalidade
Pele/patologia
Issue Date: 2007
Publisher: Lippincott Williams & Wilkins
Citation: BITTENCOURT, A. C. L. et al. Adult T-cell leukemia/lymphoma in Bahia, Brazil: analysis of prognostic factors in a group of 70 patients. American Journal of Clinical Pathology, v. 128, n. 5, p. 875-882, 2007.
DOI: 10.1309/2YGD1P0QCVCWBLDX
ISSN: 0002-9173
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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