Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10798
Title: Histopathological and immunohistochemical studies of infective dermatitis associated with HTLV-I.
Authors: Bittencourt, Achilea Candida Lisboa
Oliveira, Maria de Fátima Santos Paim de
Alves, Carlos Roberto Brites
Van Weyenbergh, Johan Jozef Rosa Maria
Vieira, Maria das Graças Silva
Araújo, Iguaracyra Barreto de Oliveira
Affilliation: Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Departamento de Patologia e Dermatologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Laboratório de Retrovirologia. Salvador, BA, Brasil
niversidade Federal da Bahia. Hospital Prof. Edgard Santos. Laboratório de Retrovirologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoregulação e Microbiologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
Abstract: Infective dermatitis associated with HTLV-I (IDH) is a chronic, recurrent, exudative eczema occurring in childhood which is considered to be a risk factor for the development of lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis. Skin biopsies from 19 patients with IDH were studied histologically and immunohistochemically using the following antibodies: anti-CD3, CD45RO, CD20, CD79a, CD4, CD8, CD56, CD57, TIA-1, granzyme-B, and perforin.A chronic dermatitis similar to atopic and seborrheic dermatitis was observed in 15 cases, whereas architectural aspects mimicking mycosis fungoides were observed in the remaining four. The infiltrate consisted predominantly of CD8+ lymphocytes and of CD57+ cells in the dermis and epidermis. TIA-1 and granzyme-B were expressed in 15/18 cases and 5/19 cases at the proportion of ≤ 15% and ≤ 3%, respectively. All cases were negative for perforin and CD56. Like other dermatites, histologically IDH may represent a benign simulator of mycosis fungoides. IDH shows a predominance of CD8+ cells and a low percentage of cells with cytotoxic granules, indicating that most CD8+ lymphocytes are not activated. These findings differ from the immunohistochemical pattern of atopic and seborrheic dermatitis, possibly representing additional means of differentiation between IDH and these dermatites. The distribution of CD57+ cells suggests that they play a role in the inflammatory process.
Keywords: HTLV-I infection
Infective dermatitis
Inflammatory simulators of mycosis fungoides
Pediatric HTLV-I-associated myelopathy/tropical spastic paraparesis
DeCS: Dermatite/patologia
Dermatite/virologia
Infecções por HTLV-I/patologia
Adolescente
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/imunologia
Dermatite/imunologia
Humanos
Imuno-Histoquímica
Linfócitos
Masculino
Issue Date: 2005
Publisher: John Libbey Eurotext [
Citation: BITTENCOURT, A. C. L. et al. Histopathological and immunohistochemical studies of infective dermatitis associated with HTLV-I. European Journal of Dermatology, v. 15, n. 1, p. 26-30, 2005.
ISSN: 1167-1122
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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