In a series of 36 cases of renal disease associated with hepatosplenic schisto- somiasis the following morphologic types of glomerulonephritis were found: me- sangio-capillary (33.2%), mesangial proliferative (25.0%), focal glomerular sclero- sis (16,75) and sclerosing glomerulonephritis (8.3%). No significant statistical differences were found when these results were compared with those from 36 cases of glomerulonephritis not associated with hepatosplenic disease. On the other hand, endocapillary glomerunonephritis was found to be predominant in the latter group of cases. These results did not substantiate the assumption that mesangio- capillary glomerulonephritis is specifically related to hepatosplenic schistosomiasis. However, if the types of glomerulonephritis that predominantly involve the me- sangium are considered together, they are significantly associated with hepatosole- nic schistosomiasis. Mesangial involvement is known to occur in other parasitic diseases and that may be related to a common immunopathogenesis.