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FATAL CRYPTOCOCCUS GATTII GENOTYPE AFLP6/VGII INFECTION IN A HIV-NEGATIVE PATIENT: CASE REPORT AND A LITERATURE REVIEW
Favalessa, Olivia Cometti et al. | Date Issued: 2014
Author
Favalessa, Olivia Cometti
Lázera, Márcia dos Santos
Wanke, Bodo
Trilles, Luciana
Takahara, Doracilde Terumi
Tadano, Tomoko
Dias, Luciana Basili
Vieira, Ananda Castro
Novack, Glaúcia Vanessa
Hahn, Rosane Christine
Affilliation
Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Micologia. Cuiabá, MT, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Micologia. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Micologia. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Micologia. Cuiabá, MT, Brasil / Universidade Federal de Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.
Abstract
Cryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV-negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5-RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8 mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy.
Keywords
Cryptococcus
Cryptococcus gattii
Brazil/ethnology
HIV Seronegativity
 
DeCS
Cryptococcus
Cryptococcus gattii
Brasil/etnologia
Soronegatividade para HIV
 
Publisher
Wiley
Citation
FAVALESSA, Olivia Cometti et al. Fatal Cryptococcus gattii genotype AFLP6/VGII infection in a HIV-negative patient: case report and a literature review. Mycoses, v.57, n.10, p.639–643, 2014.
DOI
10.1111/myc.12210
ISSN
0933-7407