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AutorPicot, Valentina Sanchez
AutorBénet, Thomas
AutorMessaoudi, Melina
AutorTelles, Jean-Nöel
AutorChou, Monidarin
AutorEap, Tekchheng
AutorWang, Jianwei
AutorShen, Kunling
AutorPape, Jean-William
AutorRouzier, Vanessa
AutorAwasthi, Shally
AutorPandey, Nitin
AutorBavdekar, Ashish
AutorSanghvi, Sonali
AutorRobinson, Annick
AutorContamin, Bénédicte
AutorHoffmann, Jonathan
AutorSylla, Maryam
AutorDiallo, Souleymane
AutorNymadawa, Pagbajabyn
AutorDash-Yandag, Budragchaagiin
AutorRussomando, Graciela
AutorBasualdo, Wilma
AutorSiqueira, Marilda Agudo Mendonça Teixeira de
AutorBarreto, Patricia
AutorKomurian-Pradel, Florence
AutorVernet, Guy
AutorEndtz, Hubert
AutorVanhems, Philippe
AutorBaccalà, Gláucia Paranhos
Fecha de acceso2015-06-17T12:05:23Z
Fecha de disponibilización2015-06-17T12:05:23Z
Fecha de publicación2014
ReferenciaPICOT, Valentina Sanchez et al. Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network). BMC Infectious Diseases, v.14:635, 9p, 2014.pt_BR
ISSN1471-2334pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/10877
Idiomaengpt_BR
EditorBioMed Centralpt_BR
Derechos de autoropen access
TítuloMulticenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)pt_BR
Tipo del documentoArticle
DOI10.1186/s12879-014-0635-8pt_BR
Resumen en InglésBackground: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design: A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion: This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónHospices Civils de Lyon. Edouard Herriot Hospital. Infection Control and Epidemiology Unit. Lyon, Grance / Universit of Lyon 1, Epidemiology and Public Health Unit. Lyon, France.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónUniversity of Health Sciences. Faculty of Pharmacy. Phnom Penh, Cambodia.pt_BR
AfiliaciónNational Pediatric Hospital. Department of Pneumology. Phnom Penh, Cambodia.pt_BR
AfiliaciónMOH Key Laboratory of Systems Biology of Pathogens. Dr. Christophe Mérieux Laboratory. Fondation Mérieux. Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College. Beijing, China.pt_BR
AfiliaciónCapital Medical University. Key Laboratory of Major Diseases in Children. National Key Discipline of Pediatrics. Ministry of Education. Beijing Pediatric Research Institute. Beijing Children’s Hospital. Capital Medical University, Beijing, China.pt_BR
AfiliaciónGHESKIO (Groupe Haïtien d’Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers. Port au Prince, Haiti.pt_BR
AfiliaciónGHESKIO (Groupe Haïtien d’Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers. Port au Prince, Haiti.pt_BR
AfiliaciónChatrapati Shahuji Maharaj University. Lucknow, India.pt_BR
AfiliaciónChatrapati Shahuji Maharaj University. Lucknow, India.pt_BR
AfiliaciónKEM Hospital Research Center. Pune, India.pt_BR
AfiliaciónKEM Hospital Research Center. Pune, India.pt_BR
AfiliaciónHôpital Femme-Mère-Enfant. Antananarivo, Madagascar.pt_BR
AfiliaciónFondation Mérieux. Centre d’Infectiologie Charles Mérieux (CICM); Antananarivo, Madagascar.pt_BR
AfiliaciónFondation Mérieux. Centre d’Infectiologie Charles Mérieux (CICM); Antananarivo, Madagascar.pt_BR
AfiliaciónGabriel Touré Hospital. Bamako, Mali.pt_BR
AfiliaciónCentre d`Infectiologie Charles Mérieux (CICM). Bamako, Mali.pt_BR
AfiliaciónMongolian Academy of Medical Sciences. Ulaanbaatar, Mongolia.pt_BR
AfiliaciónBayanzurkh District General Hospital. Ulaanbaatar, Mongolia.pt_BR
AfiliaciónResearch Institute of health. Asuncion, Paraguay.pt_BR
AfiliaciónHospital Pediátrico ! Niños de Acosta ¨Nu". San Lorenzo, Paraguay.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
AfiliaciónHospices Civils de Lyon. Edouard Herriot Hospital. Infection Control and Epidemiology Unit. Lyon, Grance / Universit of Lyon 1, Epidemiology and Public Health Unit. Lyon, France.pt_BR
AfiliaciónFondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.pt_BR
Palavras clave en InglêsPneumoniapt_BR
Palavras clave en InglêsChildrenpt_BR
Palavras clave en InglêsCase-controlpt_BR
Palavras clave en InglêsEtiologypt_BR
Palavras clave en InglêsDeveloping and emerging countriespt_BR
DeCSPneumoniapt_BR
DeCSCriançaspt_BR
DeCSPaíses em Desenvolvimentopt_BR


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