Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10881
Title: Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program
Authors: Santos, Eliane Matos dos
Sá, Gloria Regina da Silva e
Siqueira, Marilda Mendonça
Martins, Reinaldo de Menezes
Camacho, Luiz Antonio Bastos
von Doellinger, Vanessa dos Reis
Maia, Maria de Lourdes de Sousa
Affilliation: Fundação Oswaldo Cruz. Bio-Manguinhos. Unidade de Assessoria Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Unidade de Assessoria Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Unidade de Assessoria Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Unidade de Assessoria Clínica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Unidade de Assessoria Clínica. Rio de Janeiro, RJ, Brasil.
Abstract: A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles, mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro, Brazil, 2008-2009, without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007, in 1,769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses, had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0) seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination, high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immunoresponses for all three antigens and the possible need for additional doses should be studied taking into account not only serological, but also epidemiological data, as there is no serological correlate of protection for mumps.
Keywords: MMR Vaccine
Immunogenicity
Mumps
DeCS: Caxumba
Vacina contra Sarampo-Caxumba-Rubéola
Issue Date: 2014
Publisher: Fundação Oswaldo Cruz
Citation: SANTOS, Eliane Matos dos; et al. Immune response to the mumps component of the MMR vaccine in the routine of immunisation services in the Brazilian National Immunisation Program. Mem Inst Oswaldo Cruz, v.109, n.3, p.335-339, May 2014.
DOI: 10.1590/0074-0276130351
ISSN: 1678-8060
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos
ENSP - Artigos de Periódicos
IOC - Artigos de Periódicos

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