| Author | Santos, Jean Nunes dos | |
| Author | Oliveira, Gabriel Queiroz Vasconcelos | |
| Author | Gurgel, Clarissa Araújo Silva | |
| Author | Souza, Renata Oliveira de | |
| Author | Sales, Caroline Brandi Schlaepfer | |
| Author | Valença Neto, Alberto de Aguiar Pires | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Access date | 2015-06-17T16:45:18Z | |
| Available date | 2015-06-17T16:45:18Z | |
| Document date | 2009 | |
| Citation | SANTOS, J. N. et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology, v. 40, n. 4, p. 269-275, 2009. | pt_BR |
| ISSN | 1567-2379 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10900 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | pt_BR |
| Title | Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s10735-009-9238-x | |
| Abstract | Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared. | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laser Center. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Subject | Cytokeratin | pt_BR |
| Subject | Odontogenic Keratocysts | pt_BR |
| Subject | Odontogenic Neoplasms | pt_BR |
| Subject | Immunohistochemistry | pt_BR |
| DeCS | Síndrome do Nevo Basocelular/patologia | pt_BR |
| DeCS | Neoplasias Maxilomandibulares/patologia | pt_BR |
| DeCS | Queratinas/biossíntese | pt_BR |
| DeCS | Recidiva Local de Neoplasia/patologia | pt_BR |
| DeCS | Cistos Odontogênicos/patologia | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imuno-Histoquímica | pt_BR |
| DeCS | Queratinas/química | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Meis-Idade | pt_BR |
