Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10900
Title: Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors.
Authors: Santos, Jean Nunes dos
Oliveira, Gabriel Queiroz Vasconcelos
Gurgel, Clarissa Araújo Silva
Souza, Renata Oliveira de
Sales, Caroline Brandi Schlaepfer
Valença Neto, Alberto de Aguiar Pires
Ramos, Eduardo Antônio Gonçalves
Affilliation: Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laser Center. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Abstract: Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.
Keywords: Cytokeratin
Odontogenic Keratocysts
Odontogenic Neoplasms
Immunohistochemistry
DeCS: Síndrome do Nevo Basocelular/patologia
Neoplasias Maxilomandibulares/patologia
Queratinas/biossíntese
Recidiva Local de Neoplasia/patologia
Cistos Odontogênicos/patologia
Adulto
Brasil
Feminino
Humanos
Imuno-Histoquímica
Queratinas/química
Masculino
Meis-Idade
Issue Date: 2009
Publisher: Springer Verlag
Citation: SANTOS, J. N. et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology, v. 40, n. 4, p. 269-275, 2009.
DOI: 10.1007/s10735-009-9238-x
ISSN: 1567-2379
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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