Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10946
Title: Apoptosis of non-parasitised red blood cells in Plasmodium yoelii malaria
Authors: Totino, Paulo Renato Rivas
Pinna, Raquel Alves
Oliveira, Ana Cecilia Amado Xavier de
Banic, Dalma Maria
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro de Pesquisa, Diagnóstico e Tratamento em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro. RJ. Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Laboratório de Toxicologia Ambiental. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro. RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro de Pesquisa, Diagnóstico e Tratamento em Malária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro de Pesquisa, Diagnóstico e Tratamento em Malária. Rio de Janeiro, RJ, Brasil.
Abstract: Recently, while studying erythrocytic apoptosis during Plasmodium yoelii infection, we observed an increase in the levels of non-parasitised red blood cell (nRBC) apoptosis, which could be related to malarial anaemia. Therefore, in the present study, we attempted to investigate whether nRBC apoptosis is associated with the peripheral RBC count, parasite load or immune response. To this end, BALB/c mice were infected with P. yoelii 17XL and nRBC apoptosis, number of peripheral RBCs, parasitaemia and plasmatic levels of cytokines, nitric oxide and anti-RBC antibodies were evaluated at the early and late stages of anaemia. The apoptosis of nRBCs increased at the late stage and was associated with parasitaemia, but not with the intensity of the immune response. The increased percentage of nRBC apoptosis that was observed when anaemia was accentuated was not related to a reduction in peripheral RBCs. We conclude that nRBC apoptosis in P. yoelii malaria appears to be induced in response to a high parasite load. Further studies on malaria models in which acute anaemia develops during low parasitaemia are needed to identify the potential pathogenic role of nRBC apoptosis.
Keywords: Malaria
Anaemia
Red Blood cells
Apoptosis
keywords: Malária
DeCS: Eritrócitos
Anemia
Apoptose
Issue Date: 2013
Publisher: Fundação Oswaldo Cruz
Citation: TOTINO, Paulo Renato Rivas et al. Apoptosis of non-parasitised red blood cells in Plasmodium yoelii malaria. Mem Inst Oswaldo Cruz, v.108, n.6, p.686-690, Sept, 2013.
DOI: 10.1590/0074-0276108062013003
ISSN: 1678-8060
Copyright: open access
Appears in Collections:ENSP - Artigos de Periódicos
IOC - Artigos de Periódicos

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