| Author | Tarragô, Andréa Monteiro | |
| Author | Costa, Allyson Guimarães da | |
| Author | Pimentel, João Paulo Diniz | |
| Author | Gomes, Samara Tatielle Monteiro | |
| Author | Freitas, Felipe Bonfim | |
| Author | Lalwani, Pritesh | |
| Author | Araújo, Ana Ruth S. de | |
| Author | Victória, Flamir da Silva | |
| Author | Victória, Marilú Barbieri | |
| Author | Vallinoto, Antônio Carlos Rosário | |
| Author | Sadahiro, Aya | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Martins Filho, Olindo Assis | |
| Author | Malheiro, Adriana | |
| Access date | 2015-06-25T18:24:20Z | |
| Available date | 2015-06-25T18:24:20Z | |
| Document date | 2014 | |
| Citation | TARRAGÔ, Andréa Monteiro et al. Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients. Hum Immunol, vol. 75, n. 11, p. 1075-83, 2014. | pt_BR |
| ISSN | 0198-8859 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10969 | |
| Language | eng | pt_BR |
| Publisher | Elsevier/North-Holland. | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients. | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.humimm.2014.08.198 | |
| Abstract | We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV G1 patients had higher IL-2 and IFN-γ levels than G2 patients. The -174IL6G>C, -308TNFαG>A, and -1082IL10A>G variants were similarly distributed in both groups. However, HCV patients with the -174IL6GC variant had higher IL-2 and IFN-γ levels than patients with the GG and CC variants. Additionally, HCV patients with the -308TNFαGG genotype had higher IL-17A levels than patients with the AG genotype, whereas patients with the -1082IL10GG variant had higher IL-6 levels than patients with the AA and AG variants. A significant proportion of HCV patients had high levels of both IL-2 and IFN-γ. The subgroup of HCV patients with the G1/IL6CG/TNFαGG association displayed the highest proportions of high producers of IL-2 and IFN-γ whereas the subgroup with the G1/TNFαGG profile showed high proportions of high producers of IL-6 and IL-17A. HCV patients with other HCV/cytokine genotype associations showed no particular cytokine profile. Our results suggest that HCV genotype G1 and IL-6 and TNF-α polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile (IL-2 and IFN-γ) in HCV patients. | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil / Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
| Affilliation | Universidade Federal do Pará. Belém, PA, Brazil | pt_BR |
| Affilliation | Universidade Federal do Pará. Belém, PA, Brazil | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Universidade Federal do Pará. Belém, PA, Brazil | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Instituto Nacional de Pesquisas da Amazônia. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
| Subject | HCV genotype | pt_BR |
| Subject | Interleukin-10 | pt_BR |
| Subject | Interleukin-6 | pt_BR |
| Subject | Polymorphism | pt_BR |
| Subject | Tumor necrosis factor-α | pt_BR |
