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FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTITONIATE
Drug-Related Side Effects and Adverse Reactions
Hearing Loss
Tinnitus
Dizziness
Meglumine Antimoniate
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Perda Auditiva
Zumbido
Tontura
Author
Affilliation
Abstract
Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.
Keywords in Portuguese
Antimoniato de MegluminaKeywords
Leishmaniasis, MucocutaneousDrug-Related Side Effects and Adverse Reactions
Hearing Loss
Tinnitus
Dizziness
Meglumine Antimoniate
DeCS
Leishmaniose MucocutâneaEfeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Perda Auditiva
Zumbido
Tontura
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