Author | Magalhães, Vanessa Peruhype | |
Author | Martins Filho, Olindo Assis | |
Author | Prata, Aluizio | |
Author | Silva, L. de A | |
Author | Rabello, Ana | |
Author | Carvalho, Andreia Teixeira de | |
Author | Figueiredo, R. M | |
Author | Carvalho, Silvio Fernando Guimarães de | |
Author | Ferrari, T. C. A | |
Author | Van Weyenbergh, Johan Jozef Rosa Maria | |
Author | Oliveira, R. Correa | |
Access date | 2015-06-30T19:01:19Z | |
Available date | 2015-06-30T19:01:19Z | |
Document date | 2006 | |
Citation | MAGALHÃES, V. P. et al. Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection. Clinical and Experimental Immunology, v. 146, n. 1, p. 124-132, 2006. | pt_BR |
ISSN | 0009-9104 | |
URI | https://www.arca.fiocruz.br/handle/icict/11032 | |
Language | eng | pt_BR |
Publisher | British Society for Immunology | pt_BR |
Rights | open access | |
Title | Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection. | pt_BR |
Type | Article | |
DOI | 10.1111/j.1365-2249.2006.03171.x | |
Abstract | Considering the complexity of the immunological events triggered during active visceral Leishmaniasis (VL), the relevance of the segregation of the immune response during human VL into type 1 and type 2 still remains unclear. For this purpose, in individuals living in risk areas for VL, we have evaluated especially asymptomatic individuals and patients with active VL, the plasmatic levels of cytokines and reactive nitrogen species under ex vivo conditions. In addition, we have also performed an analysis of intracellular cytokine patterns of circulating leucocytes after short-term culture, particularly in the absence of antigenic-specific stimulation, in order to reflect dynamic events of immune response in vivo during Leishmania chagasi infection. Although asymptomatic individuals and non-infected subjects presented a similar immunological profile, an outstanding inflammatory/regulatory profile, based on higher plasmatic levels of cytokines such as interleukin (IL)-8, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha, IL-6 and IL-10, was associated with clinical status observed in active VL. In this context, we hypothesize that IL-10, through its ability to inhibit anti-leishmanial macrophage activation, associated with the lower frequency of TNF-alpha(+) monocytes and ordinary levels of nitrite and nitrate are the major mechanisms associated with disease onset. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina do Triângulo Mineiro. Uberaba, MG, Brasil. | pt_BR |
Affilliation | Faculdade de Medicina do Triângulo Mineiro. Uberaba, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Universidade Federal de Ouro Preto. Escola de Farmácia. Ouro Preto, MG, Brasil. | pt_BR |
Affilliation | Centro Geral de Pediatria. FHEMIG, Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Montes Claros. Montes Claros, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Cellular immune response | pt_BR |
Subject | Cytometric bead array | pt_BR |
Subject | Flow cytometry | pt_BR |
Subject | Immunoregulation | pt_BR |
Subject | Visceral Leishmaniasis | pt_BR |
DeCS | Citocinas/sangue | pt_BR |
DeCS | Leishmaniose Visceral/imunologia | pt_BR |
DeCS | Monócitos/imunologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Células Cultivadas | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imunidade Celular | pt_BR |
DeCS | Interferon gama/sangue | pt_BR |
DeCS | Interleucina-10/sangue | pt_BR |
DeCS | Leishmaniose Visceral/sangue | pt_BR |
DeCS | Leucócitos Mononucleares/imunologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Fator de Necrose Tumoral alfa/sangue | pt_BR |