Chemical composition of the hexanic fraction, antioxidant activity (DPPH assay) and total phenolic content (Folin-Ciocalteau assay) of aerial parts of sixteen Lippia species were determined. Hexanic fraction was analyzed by gas chromatography-mass spectrometry (GC-MS). The compounds β- myrcene, limonene, γ-terpinene, linalool, β-caryophyllene, germacrene D, α–copaene, β-bourbunene, β- elemene, aloaromadendrene, bicyclogermacrene, and δ-cadinene appeared in the chemical analysis in most of the Lippia hexanic fraction studied. This fraction showed low radical scavenging activity; however, the ethanolic fraction of Lippia species showed higher radical-scavenging activity than the commercial antioxidant butylated hydroxy toluene (BHT). Total phenolic content of the polar fraction, as gallic acid equivalents, ranged from 105.5 mg/g in Lippia pseudo-thea to 255.4 mg/g in Lippia sericea. The presence of phenolic compounds in the ethanolic fraction of Lippia spp. may also be the major cause of its high radical-scavenging activities.