Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/11464
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12337]
Metadata
Show full item record
ACTIVITIES OF PSILOSTACHYIN A AN CYNAROPICRIN AGAINST TRYPANOSOMA CRUZI IN VITRO AND IN VIVO
Author
Silva, Cristiane França da
Batista, Denise da Gama Jaen
Araújo, Julianna Siciliano de
Batista, Marcos Meuser
Lionel, Jessica
Souza, Ellen Mello de
Hammer, Erica Ripoll
Silva, Patricia Bernardino da
Miert, Marta de
Adams, Michael
Zimmermann, Stefanie
Hamburger, Matthias
Brun, Reto
Schühly, Wolfang
Soeiro, Maria de Nazaré Correia
Batista, Denise da Gama Jaen
Araújo, Julianna Siciliano de
Batista, Marcos Meuser
Lionel, Jessica
Souza, Ellen Mello de
Hammer, Erica Ripoll
Silva, Patricia Bernardino da
Miert, Marta de
Adams, Michael
Zimmermann, Stefanie
Hamburger, Matthias
Brun, Reto
Schühly, Wolfang
Soeiro, Maria de Nazaré Correia
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland / Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland.
University of Graz. Institute of Zoology. Graz, Austria.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland / Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland.
University of Basel. Department of Pharmaceutical Sciences, Pharmaceutical Biology. Basel, Switzerland.
Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland.
University of Graz. Institute of Zoology. Graz, Austria.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract
In vitro and in vivo activities against Trypanosoma cruzi were evaluated for two sesquiterpene lactones: psilostachyin A and cynaropicrin.
Cynaropicrin had previously been shown to potently inhibit African trypanosomes in vivo, and psilostachyin A had
been reported to show in vivo effects against T. cruzi, albeit in another test design. In vitro data showed that cynaropicrin was
more effective than psilostachyin A. Ultrastructural alterations induced by cynaropicrin included shedding events, detachment
of large portions of the plasma membrane, and vesicular bodies and large vacuoles containing membranous structures, suggestive
of parasite autophagy. Acute toxicity studies showed that one of two mice died at a cynaropicrin dose of 400 mg/kg of body
weight given intraperitoneally (i.p.). Although no major plasma biochemical alterations could be detected, histopathology demonstrated
that the liver was the most affected organ in cynaropicrin-treated animals. Although cynaropicrin was as effective as
benznidazole against trypomastigotes in vitro, the treatment (once or twice a day) of T. cruzi-infected mice (up to 50 mg/kg/day
cynaropicrin) did not suppress parasitemia or protect against mortality induced by the Y and Colombiana strains. Psilostachyin
A (0.5 to 50 mg/kg/day given once a day) was not effective in the acute model of T. cruzi infection (Y strain), reaching 100% animal
mortality. Our data demonstrate that although it is very promising against African trypanosomes, cynaropicrin does not
show efficacy compared to benznidazole in acute mouse models of T. cruzi infection.
Share